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Emerging pharmacological interventions: A COVID- 19 perspective
Annals of Phytomedicine-an International Journal ; 11(2):17-32, 2022.
Article in English | Web of Science | ID: covidwho-2241742
ABSTRACT
The current COVID- 19 pandemic caused by SARS-CoV-2 is believed to be due to zoonotic emergence. The infection leads to a variety of conditions, from mild discomfort to severe respiratory disorder requiring intensive care monitoring and at times even becoming life-threatening. The advent of multiple mutations led to variants wherein the severity and contagiousness of the disease have varied. In the initial days of the pandemic, supportive care measures such as providing oxygen for ventilation and using antivirals effective against various respiratory diseases were the pharmacological interventions used. Ongoing clinical trials are helping identify the most effective repurposed antiviral drug or a combination of such drugs to be effective against the SARS-CoV-2 infection. Researchers and healthcare personnel are putting in tremendous efforts to urgently identify prospective preventive, diagnostic and therapeutic strategies on priority. Various research institutions and pharmaceutical companies put in intensive efforts and within a short duration, many vaccines were available that helped develop population immunity, thus preventing the severity of infection even when people got infected. Candidates for therapy include the use of ( i) medicinal aromatic plant, or active phytoconstituents, individually or as a combination;(ii) nanotechnological tools to encapsulate the drugs/plant phytoconstituents;(iii) food fortification with the prepared nanoparticles, amongst some prospective strategies. As phytomedicine is gaining significance in holistic wellbeing, the research and development in the field of polyherbal have intensified. Combinational therapy is being propagated through promising results obtained by multiple researchers. In most studies, compounds used had proven potential via in vitro or in vivo studies against viruses similar to SARS- CoV-2. Further, the infection rates and the severity of the disease have been drastically reduced, with population immunity being developed due to the use of vaccines. An array of vaccines ranging from DNA, mRNA, sub-unit, viral vector and virus-like particles, are already in various stages of clinical trials, with over 12.3 billion doses being delivered globally. This is a review of scientific work conducted toward developing pharmacological interventions against COVID-19. The data represented provides a resource to researchers and healthcare providers to help control the infection and the pandemic.
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Full text: Available Collection: Databases of international organizations Database: Web of Science Type of study: Experimental Studies Language: English Journal: Annals of Phytomedicine-an International Journal Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: Web of Science Type of study: Experimental Studies Language: English Journal: Annals of Phytomedicine-an International Journal Year: 2022 Document Type: Article