Retrospective study of risk factors for mortality in critically ill patients with COVID-19
Journal of Emergency Medicine, Trauma and Acute Care
; 2022(5), 2022.
Article
in English
| EMBASE | ID: covidwho-2241856
ABSTRACT
Background:
Mortality associated with COVID-19 varies in various reports, with minimal data on the factors associated with in-hospital mortality.Objective:
To identify the risk factors for in-hospital death of patients with COVID-19 in an intensive care unit (ICU) in Qatar.Methods:
A retrospective observational study of patients confirmed with COVID-19 and admitted to the medical-surgical ICU at The Cuban Hospital was carried out from April 12, 2020, to September 12, 2020. From patients' electronic medical records, demographic, clinical, laboratory, and radiology data was collected.Results:
275 patients with COVID-19 were admitted to the ICU, and 32 (11.6%) died. 56.1% were men, and the mean age was 52.2 years. According to the univariate analysis, patients with diabetes mellitus with end-organ damage (37.5%), cardiovascular disease (31.3%), dementia (9.4%), kidney disease (28.1%), chronic obstructive pulmonary disease (31.3%), and higher Charlson index had higher mortality. According to the multivariate analysis, an increase of mortality risk by 9% was observed for each additional year of age (Odds ratio [OR] 1.09;95% confidence interval [CI] 1.04-1.14), patients on mechanical ventilation (OR 27.33;95% CI 3.21-232.46), and those with adult respiratory distress (OR 15.85;95% CI 1.45-172.82) and elevated procalcitonin (OR 7.30;95% CI 1.25-42.58), and the PiO2/FiO2 ratio between 100 and 299 decreased the risk of death by 92% (OR 0.08;95% CI 0.02-0.39), in comparison to a PiO2/FiO2 ratio less than 100 or greater than 300.Conclusion:
The study provides evidence about the risk of mortality among COVID-19 patients with a significant contribution of age, respiratory failure, and co-infections.
adult; adult respiratory distress syndrome; article; artificial ventilation; cardiovascular disease; Charlson Comorbidity Index; chronic obstructive lung disease; clinical laboratory; coinfection; controlled study; coronavirus disease 2019; critically ill patient; dementia; demography; diabetes mellitus; diabetic patient; electronic medical record; female; fraction of inspired oxygen; human; kidney disease; major clinical study; male; middle aged; mortality; mortality risk; observational study; organ injury; Qatar; radiology; respiratory failure; retrospective study; risk factor; surgical intensive care unit; univariate analysis; procalcitonin
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Journal of Emergency Medicine, Trauma and Acute Care
Year:
2022
Document Type:
Article
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