Clinical and biochemical short-term effects of hyperbaric oxygen therapy on SARS-Cov-2+ hospitalized patients with hypoxemic respiratory failure.
Respir Med
; 209: 107155, 2023 04.
Article
in English
| MEDLINE | ID: covidwho-2242077
ABSTRACT
BACKGROUND:
Hyperbaric oxygen therapy (HBOT) has been proposed to address COVID-19- associated respiratory failure. However, its biochemical effects are poorly known.METHOD:
50 patients with hypoxemic COVID-19 pneumonia were divided into C group (standard care) and H group (standard care plus HBOT). Blood was obtained at t = 0 and t = 5 days. Oxygen saturation (O2 Sat) was followed up. White blood cell (WC) count, lymphocytes (L) and platelets (P) and serum analysis (glucose, urea, creatinine, sodium, potassium, ferritin, D dimer, LDH and CRP) were carried out. Plasma levels of sVCAM, sICAM, sPselectin, SAA and MPO, and of cytokines (IL-1ß, IL-1RA, IL-6, TNFα, IFNα, IFNγ, IL-15, VEGF, MIP1α, IL-12p70, IL-2 and IP-10) were measured by multiplex assays. Angiotensin Converting Enzyme 2 (ACE-2) levels were determined by ELISA.RESULTS:
The average basal O2 Sat was 85 ± 3%. The days needed to reach O2 Sat >90% were H 3 ± 1 and C 5 ± 1 (P < 0,01). At term, H increased WC, L and P counts (all, H vs C P < 0,01). Also, H diminished D dimer levels (H vs C, P < 0,001) and LDH concentration (H vs C, P < 0.01]. At term, H showed lower levels of sVCAM, sPselectin and SAA than C with respect to basal values (H vs C ΔsVCAM P < 0,01; ΔsPselectin P < 0,05; ΔSAA P < 0,01). Similarly, H showed diminished levels of TNFα (ΔTNFα P < 0,05) and increased levels of IL-1RA and VEGF than C respect to basal values (H vs C ΔIL-1RA and ΔVEGF P < 0,05).CONCLUSION:
Patients underwent HBOT improved O2 Sat with lower levels of severity markers (WC and platelets count, D dimer, LDH, SAA). Moreover, HBOT reduced proinflammatory agents (sVCAM, sPselectin, TNFα) and increased anti-inflammatory and pro-angiogenic ones (IL-1RA and VEGF).Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Insufficiency
/
COVID-19
/
Hyperbaric Oxygenation
Type of study:
Experimental Studies
/
Prognostic study
Topics:
Long Covid
/
Variants
Limits:
Humans
Language:
English
Journal:
Respir Med
Year:
2023
Document Type:
Article
Affiliation country:
J.rmed.2023.107155
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