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Reconstruction of the origin of the first major SARS-CoV-2 outbreak in Germany.
Korencak, Marek; Sivalingam, Sugirthan; Sahu, Anshupa; Dressen, Dietmar; Schmidt, Axel; Brand, Fabian; Krawitz, Peter; Hart, Libor; Maria Eis-Hübinger, Anna; Buness, Andreas; Streeck, Hendrik.
  • Korencak M; Institute of Virology, University Hospital Bonn, Venusberg-Campus 1, Bonn 53127, Germany.
  • Sivalingam S; Institute for Genomic Statistics and Bioinformatics, Medical Faculty, University of Bonn, Venusberg-Campus 1, Bonn 53127, Germany.
  • Sahu A; Core Unit for Bioinformatics Data Analysis, Medical Faculty, University of Bonn, Venusberg-Campus 1, Bonn 53127, Germany.
  • Dressen D; Institute for Genomic Statistics and Bioinformatics, Medical Faculty, University of Bonn, Venusberg-Campus 1, Bonn 53127, Germany.
  • Schmidt A; Core Unit for Bioinformatics Data Analysis, Medical Faculty, University of Bonn, Venusberg-Campus 1, Bonn 53127, Germany.
  • Brand F; Labor Mönchengladbach MVZ Dr. Stein & Kollegen GbR, Tomphecke 45, Mönchengladbach 41169, Germany.
  • Krawitz P; Institute for Genomic Statistics and Bioinformatics, Medical Faculty, University of Bonn, Venusberg-Campus 1, Bonn 53127, Germany.
  • Hart L; Institute for Genomic Statistics and Bioinformatics, Medical Faculty, University of Bonn, Venusberg-Campus 1, Bonn 53127, Germany.
  • Maria Eis-Hübinger A; Institute for Genomic Statistics and Bioinformatics, Medical Faculty, University of Bonn, Venusberg-Campus 1, Bonn 53127, Germany.
  • Buness A; Department of Oral and Maxillofacial Surgery, University of Duisburg-Essen, Henricistr. 92, Essen 45136, Germany.
  • Streeck H; Institute of Virology, University Hospital Bonn, Venusberg-Campus 1, Bonn 53127, Germany.
Comput Struct Biotechnol J ; 20: 2292-2296, 2022.
Article in English | MEDLINE | ID: covidwho-2242289
ABSTRACT
The first major COVID-19 outbreak in Germany occurred in Heinsberg in February 2020 with 388 officially reported cases. Unexpectedly, the first outbreak happened in a small town with little to no travelers. We used phylogenetic analyses to investigate the origin and spread of the virus in this outbreak. We sequenced 90 (23%) SARS-CoV-2 genomes from the 388 reported cases including the samples from the first documented cases. Phylogenetic analyses of these sequences revealed mainly two circulating strains with 74 samples assigned to lineage B.3 and 6 samples assigned to lineage B.1. Lineage B.3 was introduced first and probably caused the initial spread. Using phylogenetic analysis tools, we were able to identify closely related strains in France and hypothesized the possible introduction from France.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Comput Struct Biotechnol J Year: 2022 Document Type: Article Affiliation country: J.csbj.2022.05.011

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Comput Struct Biotechnol J Year: 2022 Document Type: Article Affiliation country: J.csbj.2022.05.011