COVID-19 in pregnant patients with ankylosing spondylitis
International Journal of Rheumatic Diseases
; 26:196-197, 2023.
Article
in English
| EMBASE | ID: covidwho-2242327
ABSTRACT
Objective:
To describe the course of COVID-19 in women with AS during pregnancy and the effect of COVID-19 on AS activity. Material andMethods:
75 pregnant women with confirmed AS (modified New York criteria, 1984) were included for prospective observation. 26 of them were followed during the Covid-19 pandemic (03.2020 -04.2022). The average age of the patients was 33.0 ± 3.9 years, the duration of the disease was 117.0 ± 72 months. The activity according to the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in the 1st, 2nd and 3rd trimesters of pregnancy was 2.0 ± 1.4;2.0 ± 1.4 and 1.9 ± 1.5, respectively. The Ankylosing Spondylitis Disease Activity Score CRP (ASDAS-CRP) was 1.5 [1.3;2.1];1.8 [1.3;2.5] and 1.7 [1.1;2.0], respectively. The delivery period was 38.7 ± 1.6 weeks.Results:
COVID-19 was transferred to 4 pregnant women, 3 of them -at the end of the 1st -beginning of the 2nd trimester, one -at 38 weeks of pregnancy. No women have been vaccinated against COVID-19. In 3 cases, the activity of AS was low, in one -high due to axial manifestations and arthritis. In 3 women, the course of COVID-19 was mild, in one -moderate (febrile temperature for more than 3 days);only 1 woman had a dry cough. One pregnant woman canceled AS therapy (certolizumab pegol, CZP), against which the back pain of the inflammatory rhythm increased. In other cases, AS therapy was not canceled, there was no effect of COVID-19 on AS activity. (Table Presented)Conclusion:
According to preliminary data, COVID-19 in pregnant women with AS can be characterized by a mild and moderate course. There was no increase in AS activity during ongoing AS therapy.
certolizumab pegol; adult; ankylosing spondylitis; Ankylosing Spondylitis Disease Activity Score; backache; Bath ankylosing spondylitis disease activity index; conference abstract; coronavirus disease 2019; drug therapy; dry cough; female; human; major clinical study; New York; pandemic; pregnancy; pregnant woman; preliminary data; second trimester pregnancy; third trimester pregnancy
Full text:
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Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
International Journal of Rheumatic Diseases
Year:
2023
Document Type:
Article
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