Cytokine Release Syndrome and Treatment in COVID-19
Turkish Journal of Pediatric Disease
; 14(COVID-19):55-59, 2020.
Article
in English
| EMBASE | ID: covidwho-2242409
ABSTRACT
The emergent outbreak of coronavirus disease 2019 (COVID-19) is a global health problem and has been recognized as a pandemic. Although COVID-19 leads to mild flu-like symptoms in most patients, the disease may cause frequently fatal, severe complications, such as acute respiratory distress syndrome and cytokine release syndrome. In these patients, defects in lymphocytic cytolytic activity trigger the proinflammatory cytokine cascade, and then "cytokine storm” begins. As a result, it leads to uncontrolled active macrophage entry into the tissues and hemophagocytosis. Here, the responses of host cells, cytokine release syndrome and the therapeutic approaches to alleviate the cytokine storm in COVID-19 will be reviewed.
adult; adult respiratory distress syndrome; complication; coronavirus disease 2019; cytokine release; cytokine release syndrome; cytokine storm; erythrophagocytosis; flu like syndrome; global health; host cell; human; human cell; immune response; lymphocyte; macrophage; pandemic; review; cytokine; endogenous compound; tocilizumab
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Turkish Journal of Pediatric Disease
Year:
2020
Document Type:
Article
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