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Bat Red Blood Cells Express Nucleic Acid-Sensing Receptors and Bind RNA and DNA.
Lam, L K Metthew; Dobkin, Jane; Eckart, Kaitlyn A; Gereg, Ian; DiSalvo, Andrew; Nolder, Amber; Anis, Eman; Ellis, Julie C; Turner, Greg; Mangalmurti, Nilam S.
  • Lam LKM; Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Dobkin J; Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Eckart KA; Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Gereg I; Department of Pathobiology, Wildlife Futures Program, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA.
  • DiSalvo A; Bureau of Wildlife Management, Pennsylvania Game Commission, Harrisburg, PA; and.
  • Nolder A; Bureau of Wildlife Management, Pennsylvania Game Commission, Harrisburg, PA; and.
  • Anis E; Department of Pathobiology, Wildlife Futures Program, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA.
  • Ellis JC; Department of Pathobiology, Wildlife Futures Program, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA.
  • Turner G; Bureau of Wildlife Management, Pennsylvania Game Commission, Harrisburg, PA; and.
  • Mangalmurti NS; Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; nspatel@pennmedicine.upenn.edu.
Immunohorizons ; 6(5): 299-306, 2022 05 20.
Article in English | MEDLINE | ID: covidwho-2242460
ABSTRACT
RBCs demonstrate immunomodulatory capabilities through the expression of nucleic acid sensors. However, little is known about bat RBCs, and no studies have examined the immune function of bat erythrocytes. In this study, we show that bat RBCs express the nucleic acid-sensing TLRs TLR7 and TLR9 and bind the nucleic acid ligands, ssRNA, and CpG DNA. Collectively, these data suggest that, like human RBCs, bat erythrocytes possess immune function and may be reservoirs for nucleic acids. These findings provide unique insight into bat immunity and may uncover potential mechanisms by which virulent pathogens of humans are concealed in bats.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Nucleic Acids / Chiroptera Limits: Animals / Humans Language: English Journal: Immunohorizons Year: 2022 Document Type: Article Affiliation country: Immunohorizons.2200013

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Nucleic Acids / Chiroptera Limits: Animals / Humans Language: English Journal: Immunohorizons Year: 2022 Document Type: Article Affiliation country: Immunohorizons.2200013