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A comparative bibliometric analysis of Omicron and Delta variants during the COVID-19 pandemic.
Liu, Yang-Xi; Wang, Li-Hui; Zhu, Cheng; Zha, Qiong-Fang; Yu, Yue-Tian.
  • Liu YX; Department of Pharmacy, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
  • Wang LH; Department of Critical Care Medicine, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
  • Zhu C; Department of Disease Prevention and Control, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
  • Zha QF; Department of Respiratory and Critical Care Medicine, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
  • Yu YT; Department of Critical Care Medicine, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
Ann Palliat Med ; 12(1): 60-69, 2023 01.
Article in English | MEDLINE | ID: covidwho-2242811
ABSTRACT

BACKGROUND:

To compare the research hotspots of infections with the Delta and Omicron variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the coronavirus disease 2019 (COVID-19) pandemic and to identify future research trends.

METHODS:

Studies about Delta and Omicron variant infections published over the last 3 years were retrieved from the Web of Science (WoS) database. A comparative bibliometric analysis was conducted through machine learning and visualization tools, including VOSviewer, Bibliographic Item Co-Occurrence Matrix Builder, and Graphical Clustering Toolkit. Research hotspots and trends in the field were analyzed, and the contributions and collaborations of countries, institutions, and authors were documented. A cross-sectional analysis of the relevant studies registered at ClinicalTrials.gov was also performed to clarify the direction of future research.

RESULTS:

A total of 1,787 articles distributed in 107 countries and 374 publications from 77 countries focused on the Delta and Omicron variants were included in our bibliometric analysis. The top five productive countries in both variants were the USA, China, the UK, India, and Germany. In 5,999 and 1,107 keywords identified from articles on the Delta and Omicron, the top two frequent keywords were the same "COVID-19" (occurrence 713, total link strength 1,525 in Delta; occurrence 137, total link strength 354 in Omicron), followed by "SARS-CoV-2" (occurrence 553, total link strength 1,478 in Delta; occurrences 132, total link strength 395 in Omicron). Five theme clusters from articles on Delta variant were identified transmission, molecular structure, activation mode, epidemiology, and co-infection. While other three theme clusters were recognized for the Omicron variant vaccine, human immune response, and infection control. Meanwhile, 21 interventional studies had been registered up to April 2022, most of which aimed to evaluate the immunogenicity and safety of different kinds of vaccines in various populations.

CONCLUSIONS:

Publications and clinical trials related to COVID-19 increased annually. As the first comparative bibliometric analysis for Delta and Omicron variants, we noticed that the relevant research trends have shifted from vaccine development to infection control and management of complications. The ongoing clinical studies will verify the safety and efficacy of promising drugs.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Language: English Journal: Ann Palliat Med Year: 2023 Document Type: Article Affiliation country: Apm-22-1111

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Language: English Journal: Ann Palliat Med Year: 2023 Document Type: Article Affiliation country: Apm-22-1111