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Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets.
Loganathan, Tamizhini; Doss C, George Priya.
  • Loganathan T; Laboratory of Integrative Genomics, Department of Integrative Biology, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore- 632014, Tamil Nadu, India.
  • Doss C GP; Laboratory of Integrative Genomics, Department of Integrative Biology, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore- 632014, Tamil Nadu, India. georgepriyadoss@vit.ac.in.
Funct Integr Genomics ; 23(1): 33, 2023 Jan 10.
Article in English | MEDLINE | ID: covidwho-2242834
ABSTRACT
Human diseases have been a critical threat from the beginning of human history. Knowing the origin, course of action and treatment of any disease state is essential. A microscopic approach to the molecular field is a more coherent and accurate way to explore the mechanism, progression, and therapy with the introduction and evolution of technology than a macroscopic approach. Non-coding RNAs (ncRNAs) play increasingly important roles in detecting, developing, and treating all abnormalities related to physiology, pathology, genetics, epigenetics, cancer, and developmental diseases. Noncoding RNAs are becoming increasingly crucial as powerful, multipurpose regulators of all biological processes. Parallel to this, a rising amount of scientific information has revealed links between abnormal noncoding RNA expression and human disorders. Numerous non-coding transcripts with unknown functions have been found in addition to advancements in RNA-sequencing methods. Non-coding linear RNAs come in a variety of forms, including circular RNAs with a continuous closed loop (circRNA), long non-coding RNAs (lncRNA), and microRNAs (miRNA). This comprises specific information on their biogenesis, mode of action, physiological function, and significance concerning disease (such as cancer or cardiovascular diseases and others). This study review focuses on non-coding RNA as specific biomarkers and novel therapeutic targets.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: MicroRNAs / RNA, Long Noncoding / Neoplasms Type of study: Prognostic study Limits: Humans Language: English Journal: Funct Integr Genomics Journal subject: Molecular Biology / Genetics Year: 2023 Document Type: Article Affiliation country: S10142-022-00947-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: MicroRNAs / RNA, Long Noncoding / Neoplasms Type of study: Prognostic study Limits: Humans Language: English Journal: Funct Integr Genomics Journal subject: Molecular Biology / Genetics Year: 2023 Document Type: Article Affiliation country: S10142-022-00947-4