Severe COVID-19 is associated with molecular signatures of aging in the human brain.

Mavrikaki, Maria; Lee, Jonathan D; Solomon, Isaac H; Slack, Frank J

Mavrikaki, Maria; Lee, Jonathan D; Solomon, Isaac H; Slack, Frank J.

Mavrikaki M; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. mmavrika@bidmc.harvard.edu.
Lee JD; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Solomon IH; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Slack FJ; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. fslack@bidmc.harvard.edu.

Nat Aging ; 2(12): 1130-1137, 2022 12.

Article in English | MEDLINE | ID: covidwho-2243217

ABSTRACT

ABSTRACT

As coronavirus disease 2019 (COVID-19) and aging are both accompanied by cognitive decline, we hypothesized that COVID-19 might lead to molecular signatures similar to aging. We performed whole-transcriptome analysis of the frontal cortex, a critical area for cognitive function, in individuals with COVID-19, age-matched and sex-matched uninfected controls, and uninfected individuals with intensive care unit/ventilator treatment. Our findings indicate that COVID-19 is associated with molecular signatures of brain aging and emphasize the value of neurological follow-up in recovered individuals.

Subject(s)

COVID-19; Humans; Aging/genetics; Brain; Frontal Lobe; Gene Expression Profiling

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Prognostic study Limits: Humans Language: English Journal: Nat Aging Year: 2022 Document Type: Article Affiliation country: S43587-022-00321-w

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