Your browser doesn't support javascript.
Clinical performance of rapid antigen tests in comparison to RT-PCR for SARS-COV-2 diagnosis in Omicron variant: A systematic review and meta-analysis.
Mohammadie, Zahra Eslami; Akhlaghi, Saeed; Samaeinasab, Saeed; Shaterzadeh-Bojd, Shakiba; Jamialahmadi, Tannaz; Sahebkar, Amirhossein.
  • Mohammadie ZE; Student Research Committee, Faculty of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Akhlaghi S; Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Samaeinasab S; Immunology Board for Transplantation and Cell-Based Therapeutics (Immuno_TACT), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
  • Shaterzadeh-Bojd S; Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Jamialahmadi T; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Sahebkar A; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Rev Med Virol ; 33(2): e2428, 2023 03.
Article in English | MEDLINE | ID: covidwho-2243408
ABSTRACT
The Omicron variant of concern has a high level of mutations in different genes that has raised awareness about the performance of immunological products such as vaccines and antigen detection kits. In this systematic review and meta-analysis, we investigated whether Omicron had a significant influence on rapid antigen test (RAT) performance in comparison to PCR. We registered this systematic review and meta-analysis in PROSPERO with the registration number CRD42022355510. We searched PubMed, Scopus, Embase, and Web of Science databases systematically to 1 August 2022. After article screening, we assessed the quality of the included studies based on the JBI checklist. Following data extraction, we performed a meta-analysis using R software. We included 18 qualified articles presenting sufficient data about RATs performance in comparison to RT-PCR in Omicron infections. The pooled specificity and sensitivity of RATs were 1.000 (0.997-1.000) and 0.671 (0.595-0.721), respectively. The FDA-approved kits showed a better performance than WHO-approved ones with a sensitivity of 0.728 (0.620-0.815). The use of RATs with nasal swabs showed a higher sensitivity compared with nasopharyngeal swabs. The sensitivity for samples with a CT-value >25 was 0.108 (0.048-0.227). Rapid antigen tests show impaired performance for COVID-19 diagnosis when the Omicron variant is circulating, particularly in samples with low viral loads.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Vaccines / Variants Limits: Humans Language: English Journal: Rev Med Virol Journal subject: Virology Year: 2023 Document Type: Article Affiliation country: Rmv.2428

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Vaccines / Variants Limits: Humans Language: English Journal: Rev Med Virol Journal subject: Virology Year: 2023 Document Type: Article Affiliation country: Rmv.2428