Your browser doesn't support javascript.
Predictors of in-hospital mortality in HIV-infected patients with COVID-19.
Moreno-Torres, Víctor; de Mendoza, Carmen; Martínez-Urbistondo, María; Mills, Patricia; Treviño, Ana; de la Fuente, Sara; Díaz de Santiago, Alberto; Calderón-Parra, Jorge; Pintos-Pascual, Ilduara; Corpas, Manuel; Soriano, Vicente.
  • Moreno-Torres V; Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • de Mendoza C; Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Martínez-Urbistondo M; UNIR Health Sciences School and Medical Center, Madrid, Spain.
  • Mills P; Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Treviño A; Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • de la Fuente S; UNIR Health Sciences School and Medical Center, Madrid, Spain.
  • Díaz de Santiago A; Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Calderón-Parra J; Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Pintos-Pascual I; Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Corpas M; Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Soriano V; UNIR Health Sciences School and Medical Center, Madrid, Spain.
QJM ; 2022 Sep 01.
Article in English | MEDLINE | ID: covidwho-2243485
ABSTRACT

BACKGROUND:

Underlying immunodeficiency is associated with severe COVID-19, but the prognosis of persons with HIV (PWH) with COVID-19 is under debate.

METHODS:

Nationwide, retrospective, observational analysis of all hospitalizations with COVID-19 during year 2020 in Spain. Stratification was made according to HIV status. The National Registry of Hospital Discharges was used with the ICD-10 coding list.

RESULTS:

A total of 117,694 adults were hospitalized with COVID-19 during 2020. Only 234 (0.2%) were HIV-positives. More than 95% were on antiretroviral therapy. Compared to HIV-negatives, PWH were younger (mean age 53.2 vs 66.5 years-old; p < 0.001) and more frequently male (74.8% vs 56.6%; p < 0.001). Most co-morbidities predisposing to severe COVID-19 (diabetes, hypertension, dementia, cardiovascular disease) were more frequent in HIV-negatives. In contrast, the rate of baseline liver disease was over 6-fold higher in PWH (27.4% vs 4.4%; p < 0.001). In-hospital mortality was lower in PWH (9.4% vs 16%; p = 0.004). In multivariate analysis, older age, dementia and especially advanced liver disease (RR 7.6) were the major determinants of death in PWH hospitalized with COVID-19.

CONCLUSION:

HIV-infected patients hospitalized in Spain with COVID-19 during 2020 had better survival than HIV-negatives, most likely explained by younger age and lower rate of co-morbidities. However, advanced liver disease was a major predictor of death in PWH hospitalized with COVID-19.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: Qjmed

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: Qjmed