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SARS-CoV-2 infection might be a predictor of mortality in intracerebral hemorrhage.
Mowla, Ashkan; Shakibajahromi, Banafsheh; Shahjouei, Shima; Baharvahdat, Humain; Harandi, Ali Amini; Rahmani, Farzad; Mondello, Stefania; Rahimian, Nasrin; Cernigliaro, Achille; Hokmabadi, Elyar Sadeghi; Ebrahimzadeh, Seyed Amir; Ramezani, Mahtab; Mehrvar, Kaveh; Farhoudi, Mehdi; Naderi, Soheil; Fenderi, Shahab Mahmoudnejad; Pishjoo, Masoud; Alizada, Orkhan; Purroy, Francisco; Requena, Manuel; Tsivgoulis, Georgios; Zand, Ramin.
  • Mowla A; Division of Stroke and Endovascular Neurosurgery, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, California, USA.
  • Shakibajahromi B; Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Shahjouei S; Neurology Department, Neuroscience Institute, Geisinger Health System, PA, USA.
  • Baharvahdat H; Division of Neuroendovascular Surgery, Department of Neurosurgery, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Harandi AA; Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Rahmani F; Department of Emergency Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Mondello S; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
  • Rahimian N; Department of Neurology, Tufts Medical Center, Boston, MA, USA.
  • Cernigliaro A; Regional Health Authority of Sicily, Palermo, Italy.
  • Hokmabadi ES; Neurosciences Resarch Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Ebrahimzadeh SA; Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Ramezani M; Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mehrvar K; Department of Neurology, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
  • Farhoudi M; Neurosciences Resarch Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Naderi S; Neurosurgery Department, Tehran University of Medical Sciences, Tehran, Iran.
  • Fenderi SM; Division of Neuroendovascular Surgery, Department of Neurosurgery, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Pishjoo M; Division of Neuroendovascular Surgery, Department of Neurosurgery, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Alizada O; Department of Neurosurgery, Baskent University, Faculty of Medicine, Istanbul, Turkey.
  • Purroy F; Department of Neurology, Hospital Arnau de Vilanova, Institut de Recerca Biomèdica de Lleida (IRBLLeida), Universitat de Lleida UdL Lleida, Spain.
  • Requena M; Stroke Unit, Department of Neurology, Hospital Vall d'Hebron, Department de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Tsivgoulis G; Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.
  • Zand R; Neurology Department, Neuroscience Institute, Geisinger Health System, PA, USA. Electronic address: rzand@geisinger.edu.
J Neurol Sci ; 444: 120497, 2022 Nov 24.
Article in English | MEDLINE | ID: covidwho-2243520
ABSTRACT

BACKGROUND:

SARS-CoV-2 infection may be associated with uncommon complications such as intracerebral hemorrhage (ICH), with a high mortality rate. We compared a series of hospitalized ICH cases infected with SARS-CoV-2 with a non-SARS-CoV-2 infected control group and evaluated if the SARS-CoV-2 infection is a predictor of mortality in ICH patients.

METHODS:

In a multinational retrospective study, 63 cases of ICH in SARS-CoV-2 infected patients admitted to 13 tertiary centers from the beginning of the pandemic were collected. We compared the clinical and radiological characteristics and in-hospital mortality of these patients with a control group of non-SARS-CoV-2 infected ICH patients of a previous cohort from the country where the majority of cases were recruited.

RESULTS:

Among 63 ICH patients with SARS-CoV-2 infection, 23 (36.5%) were women. Compared to the non-SARS-CoV-2 infected control group, in SARS-CoV-2 infected patients, ICH occurred at a younger age (61.4 ± 18.1 years versus 66.8 ± 16.2 years, P = 0.044). These patients had higher median ICH scores ([3 (IQR 2-4)] versus [2 (IQR 1-3)], P = 0.025), a more frequent history of diabetes (34% versus 16%, P = 0.007), and lower platelet counts (177.8 ± 77.8 × 109/L versus 240.5 ± 79.3 × 109/L, P < 0.001). The in-hospital mortality was not significantly different between cases and controls (65% versus 62%, P = 0.658) in univariate analysis; however, SARS-CoV-2 infection was significantly associated with in-hospital mortality (aOR = 4.3, 95% CI 1.28-14.52) in multivariable analysis adjusting for potential confounders.

CONCLUSION:

Infection with SARS-CoV-2 may be associated with increased odds of in-hospital mortality in ICH patients.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Journal: J Neurol Sci Year: 2022 Document Type: Article Affiliation country: J.jns.2022.120497

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Journal: J Neurol Sci Year: 2022 Document Type: Article Affiliation country: J.jns.2022.120497