CASE REPORT: A RARE CASE OF ALVEOLAR HEMORRHAGE AFTER COVID-19 VACCINATION IN A PATIENT WITH RENAL-LIMITED ANTINEUTROPHIL CYTOPLASMIC ANTIBODYASSOCIATED VASCULITIS
Journal of Hypertension
; 41:e443, 2023.
Article
in English
| EMBASE | ID: covidwho-2243791
ABSTRACT
The coronavirus disease 2019 (COVID-19) vaccination campaign has progressed worldwide. Rare but severe adverse events of COVID-19 vaccination such as anaphylaxis and myocarditis have begun to be noticed. Of note, several cases of new-onset antineutrophil cytoplasmic antibody-associated vasculitis (AAV) after COVID-19 mRNA vaccination have been reported. In contrast, relapse of AAV in remission has not been recognized enough as an adverse outcome of COVID-19 vaccination. We report, to the best of our knowledge, a first case of renal-limited AAV in remission using every 6-month rituximab administration that relapsed with pulmonary hemorrhage, but not glomerulonephritis, following the first dose of the COVID-19 vaccine. Notably, the patient received the COVID-19 vaccine more than 6 months after the last dose of rituximab according to the recommendations. Ironically, his CD19 positive B cell counts were found to be increased after admission, indicating that our case might have been prone to relapse after COVID-19 vaccination. Although our case cannot establish causality between AAV relapse and COVID-19 mRNA vaccination, a clinical vigilance for relapse of AAV especially in patients undergoing rituximab maintenance therapy following COVID-19 vaccination should be maintained. Furthermore, the elapsed time between rituximab administration and COVID-19 mRNA vaccination should be carefully adjusted based on AAV disease-activity (Nishioka et al. Front Med 2022. in press).
CD19 antigen; endogenous compound; messenger RNA; neutrophil cytoplasmic antibody; rituximab; SARS-CoV-2 vaccine; adult; adverse outcome; alertness; B lymphocyte; case report; causality; cell count; clinical article; conference abstract; coronavirus disease 2019; drug therapy; glomerulonephritis; human; lung hemorrhage; maintenance therapy; male; outcome assessment; relapse; remission; side effect; vaccination; vasculitis
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Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Case report
Topics:
Vaccines
Language:
English
Journal:
Journal of Hypertension
Year:
2023
Document Type:
Article
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