Your browser doesn't support javascript.
One-year mortality in COVID-19 is associated with patients' comorbidities rather than pneumonia severity.
Novelli, Luca; Raimondi, Federico; Carioli, Greta; Carobbio, Alessandra; Pappacena, Simone; Biza, Roberta; Trapasso, Roberta; Anelli, Marisa; Amoroso, Mariangela; Allegri, Chiara; Malandrino, Luca; Imeri, Gianluca; Conti, Caterina; Beretta, Marta; Gori, Mauro; D'Elia, Emilia; Senni, Michele; Lorini, Ferdinando Luca; Rizzi, Marco; Cosentini, Roberto; Rambaldi, Alessandro; Masciulli, Arianna; Gavazzi, Antonello; Solidoro, Paolo; Sironi, Sandro; Fagiuoli, Stefano; Barbui, Tiziano; Marco, Fabiano Di.
  • Novelli L; Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Raimondi F; Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Health Sciences, University of Milan, Milan, Italy. Electronic address: fraimondi@asst-pg23.it.
  • Carioli G; Fondazione per la Ricerca Ospedale Maggiore di Bergamo (FROM), Bergamo, Italy.
  • Carobbio A; Fondazione per la Ricerca Ospedale Maggiore di Bergamo (FROM), Bergamo, Italy.
  • Pappacena S; Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Health Sciences, University of Milan, Milan, Italy.
  • Biza R; Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Health Sciences, University of Milan, Milan, Italy.
  • Trapasso R; Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Health Sciences, University of Milan, Milan, Italy.
  • Anelli M; Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Health Sciences, University of Milan, Milan, Italy.
  • Amoroso M; Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Health Sciences, University of Milan, Milan, Italy.
  • Allegri C; Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Health Sciences, University of Milan, Milan, Italy.
  • Malandrino L; Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Health Sciences, University of Milan, Milan, Italy.
  • Imeri G; Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Conti C; Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Beretta M; Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Gori M; Cardiology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • D'Elia E; Cardiology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Senni M; Cardiology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
  • Lorini FL; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; Department of Intensive Critical Care, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Rizzi M; Infectious Diseases Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Cosentini R; Emergency Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Rambaldi A; Department of Health Sciences, University of Milan, Milan, Italy; Hematology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Masciulli A; Fondazione per la Ricerca Ospedale Maggiore di Bergamo (FROM), Bergamo, Italy.
  • Gavazzi A; Fondazione per la Ricerca Ospedale Maggiore di Bergamo (FROM), Bergamo, Italy.
  • Solidoro P; Unit of Pneumology, Department of Cardiovascular and Thoracic Surgery, Molinette Hospital, Città della Salute e della Scienza, University of Turin, Italy.
  • Sironi S; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; Department of Diagnostic Radiology, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Fagiuoli S; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; Gastroenterlogy 1, Hepatology and Transplantation Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Barbui T; Fondazione per la Ricerca Ospedale Maggiore di Bergamo (FROM), Bergamo, Italy.
  • Marco FD; Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Health Sciences, University of Milan, Milan, Italy.
Respir Med Res ; 83: 100976, 2022 Nov 25.
Article in English | MEDLINE | ID: covidwho-2243817
ABSTRACT

BACKGROUND:

In patients with pneumonia or acute respiratory distress syndrome who survived hospitalization, one-year mortality can affect up to one third of discharged patients. Therefore, significant long-term mortality after COVID-19 respiratory failure could be expected. The primary outcome of the present study was one-year all-cause mortality in hospitalized COVID-19 patients.

METHODS:

Observational study of COVID-19 patients hospitalized at Papa Giovanni XXIII Hospital (Bergamo, Italy), during the first pandemic wave.

RESULTS:

A total of 1326 COVID-19 patients were hospitalized. Overall one-year mortality was 33.6% (N 446/1326), with the majority of deaths occurring during hospitalization (N=412, 92.4%). Thirty-four patients amongst the 914 discharged (3.7%) subsequentely died within one year. A third of these patients died for advanced cancer, while death without a cause other than COVID-19 was uncommon (8.8% of the overall post-discharge mortality). In-hospital late mortality (i.e. after 28 days of admission) interested a population with a lower age, and fewer comorbidities, more frequentely admitted in ICU. Independent predictors of post-discharge mortality were age over 65 years (HR 3.19; 95% CI 1.28-7.96, p-value=0.013), presence of chronic obstructive pulmonary disease (COPD) (HR 2.52; 95% CI 1.09-5.83, p-value=0.031) or proxy of cardiovascular disease (HR 4.93; 95% CI 1.45-16.75, p-value=0.010), and presence of active cancer (HR 3.64; 95% CI 1.50-8.84, p-value=0.004), but not pneumonia severity.

CONCLUSIONS:

One-year post-discharge mortality depends on underlying patients' comorbidities rather than COVID-19 pneumonia severity per se. Awareness among physicians of predictors of post-discharge mortality might be helpful in structuring a follow-up program for discharged patients.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Language: English Journal: Respir Med Res Year: 2022 Document Type: Article Affiliation country: J.resmer.2022.100976

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Language: English Journal: Respir Med Res Year: 2022 Document Type: Article Affiliation country: J.resmer.2022.100976