Your browser doesn't support javascript.
Association between Glutathione S-Transferases Gene Variants and COVID-19 Severity in Previously Vaccinated and Unvaccinated Polish Patients with Confirmed SARS-CoV-2 Infection.
Orlewska, Katarzyna; Klusek, Justyna; Zarebska-Michaluk, Dorota; Kocanda, Kamila; Oblap, Ruslan; Cedro, Anna; Witczak, Bartosz; Klusek, Jolanta; Sliwczynski, Andrzej; Orlewska, Ewa.
  • Orlewska K; Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland.
  • Klusek J; Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland.
  • Zarebska-Michaluk D; Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland.
  • Kocanda K; Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland.
  • Oblap R; Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland.
  • Cedro A; Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland.
  • Witczak B; Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland.
  • Klusek J; Institute of Biology, Jan Kochanowski University, 25-406 Kielce, Poland.
  • Sliwczynski A; Faculty of Medicine, Lazarski University, 02-662 Warsaw, Poland.
  • Orlewska E; Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, Poland.
Int J Environ Res Public Health ; 20(4)2023 Feb 20.
Article in English | MEDLINE | ID: covidwho-2243938
ABSTRACT
As the outcome of COVID-19 is associated with oxidative stress, it is highly probable that polymorphisms of genes related to oxidative stress were associated with susceptibility and severity of COVID-19. The aim of the study was to assess the association of glutathione S-transferases (GSTs) gene polymorphisms with COVID-19 severity in previously vaccinated and unvaccinated Polish patients with confirmed SARS-CoV-2 infection. A total of 92 not vaccinated and 84 vaccinated patients hospitalized due to COVID-19 were included. The WHO COVID-19 Clinical Progression Scale was used to assess COVID-19 severity. GSTs genetic polymorphisms were assessed by appropriate PCR methods. Univariable and multivariable analyses were performed, including logistic regression analysis. GSTP1 Ile/Val genotype was found to be associated with a higher risk of developing a severe form of the disease in the population of vaccinated patients with COVID-19 (OR 2.75; p = 0.0398). No significant association was observed for any of the assessed GST genotypes with COVID-19 disease severity in unvaccinated patients with COVID-19. In this group of patients, BMI > 25 and serum glucose level > 99 mg% statistically significantly increased the odds towards more severe COVID-19. Our results may contribute to further understanding of risk factors of severe COVID-19 and selecting patients in need of strategies focusing on oxidative stress.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Glutathione Transferase Type of study: Prognostic study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: Europa Language: English Year: 2023 Document Type: Article Affiliation country: Ijerph20043752

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Glutathione Transferase Type of study: Prognostic study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: Europa Language: English Year: 2023 Document Type: Article Affiliation country: Ijerph20043752