Why doesn't Ebola virus cause pandemics like SARS-CoV-2?
Microb Risk Anal
; 22: 100236, 2022 Dec.
Article
in English
| MEDLINE | ID: covidwho-2244306
ABSTRACT
Ebola virus is among the most dangerous, contagious and deadly etiological causes of viral diseases. However, Ebola virus has never extensively spread in human population and never have led to a pandemic. Why? The mechanistic biophysical model revealing the biothermodynamic background of virus-host interaction) could help us to understand pathogenesis of Ebola virus disease (earlier known as the Ebola hemorrhagic fever). In this paper for the first time the empirical formula, thermodynamic properties of biosynthesis (including the driving force of virus multiplication in the susceptible host), binding constant and thermodynamic properties of binding are reported. Thermodynamic data for Ebola virus were compared with data for SARS-CoV-2 to explain why SARS-CoV-2 has caused a pandemic, while Ebola remains on local epidemic level. The empirical formula of the Ebola virus was found to be CH1.569O0.3281N0.2786P0.00173S0.00258. Standard Gibbs energy of biosynthesis of the Ebola virus nucleocapsid is -151.59 kJ/C-mol.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Etiology study
Language:
English
Journal:
Microb Risk Anal
Year:
2022
Document Type:
Article
Affiliation country:
J.mran.2022.100236
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