Multidisciplinary management of a quickly growing pediatric atypical Spitz nevus, mimicking melanoma, during the COVID-19 pandemic
Journal of Pediatric Surgery Case Reports
; 88, 2023.
Article
in English
| Scopus | ID: covidwho-2244314
ABSTRACT
Spitzoid melanoma is very rare tumour in the pediatric population, with clinical and non-uniform behaviour, different from adult melanoma [1]. It can be difficult to differentiate an atypical Spitz nevus from a Spitzoid melanoma, resulting in diagnostic problems. In addition, in our clinical case, the COVID-19pandemiccaused significant delays both in the diagnosis and in the surgical treatment of our patient. We present the clinical case of a 4-year-old child suffering from a localized polypoid cutaneous neoformation on the dorsum of the left hand, which started immediately before the lockdown and steadily increased during the COVID-19 pandemic. After a general clinical framing, the child underwent an excisional biopsy at our Department of Plastic and Reconstructive Surgery, at the Policlinico of Foggia. Subsequently, two independent anatomic pathology groups examined the specimen. Definitive diagnosis was made only after careful genetic analysis in combination with supporting histological and immunohistochemical examinations. This clinical case shows how during the pandemic we have been facing advanced forms of tumours, compared to the previous period and highlight show an interdisciplinary and multicenter collaboration allowed a quick diagnosis of certainty, demonstrating the utility of molecular pathology as a fundamental aid in clinical/surgical practice. © 2022 The Authors
antibiotic agent; corticosteroid; Ki 67 antigen; melan A; protein p16; anamnesis; Article; atypical Spitz nevus; case report; cell infiltration; cell maturation; child; clinical article; clinical examination; clinical monitoring; clinical outcome; coronavirus disease 2019; cytology; disease exacerbation; epidermis; epithelioid histiocyte; excisional biopsy; follow up; genetic analysis; hand; histopathology; human; human cell; human tissue; immunohistochemistry; inflammation; lymphomonocyte; male; melanocyte; melanoma; mitosis; mitosis index; morphological trait; pandemic; patient referral; preschool child; risk factor; skin defect; skin thickness; skin ulcer; surgical margin; Covid-19 pandemic; Pediatric Spitz melanoma
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Collection:
Databases of international organizations
Database:
Scopus
Language:
English
Journal:
Journal of Pediatric Surgery Case Reports
Year:
2023
Document Type:
Article
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