Retrospective Analysis of C - Reactive Protein, Haematological Biomarkers and Coagulation Profile in Patients of SARS-Cov-2 in a Tertiary Care Hospital of Eastern India
International Journal of Pharmaceutical Sciences Review and Research
; 78(1):88-93, 2023.
Article
in English
| EMBASE | ID: covidwho-2244800
ABSTRACT
Introduction:
Blood tests play an important role in the early detection of disease given that they provide doctors with information about inflammatory processes. A complete blood count (CBC) is easy and inexpensive to perform. These parameters can be used alone as markers of inflammation. Their mutual ratio is also an indicator of early inflammation.4 In light of previous studies, the use of circulating biomarkers instead of inflammation and immune system has been considered a prognostic indicator for COVID-19 positive patients. Aims/objective:
To examines the role of biomarkers from peripheral blood samples in the diagnosis of hospitalized COVID-19 patients with a history of fever. Materials andMethod:
Haematological biomarkers and coagulation profile was compared between RT-PCR positive and negative patients. Systemic inflammatory index (SII) was calculated by multiplying thrombocyte count with neutrophil count and dividing the value by lymphocyte count. Neutrophil lymphocyte ratio (NLR) was calculated by dividing absolute neutrophil count by absolute lymphocyte count. Platelet lymphocyte ratio (PLR) was calculated by dividing absolute platelet by absolute lymphocyte count. Fisher exact test and unpaired t-test were used to compare categorical and continuous data respectively.Results:
Analysis was done on 57 retrospective cases of RT-PCR positive patients and 61 RT-PCR negative patients with history of fever. COVID-19 positive patients showed leukopenia, neutropenia, thrombocytopenia, and lymphocytosis. SII and NLR decreased and PLR increased. PT and APTT were generally within normal limits in most of the patients. There was significant difference between two groups with respect to lymphocyte counts and PLR.Conclusion:
The most standardized non-invasive and inexpensive tests such as CBC, coagulation and biochemical tests are available to assess disease severity for wise allocation of medical resources in developing countries such as India where resources and care are limited.
absolute lymphocyte count; absolute neutrophil count; activated partial thromboplastin time; adult; article; blood cell count; blood sampling; controlled study; coronavirus disease 2019; developing country; diagnosis; female; fever; Fisher exact test; human; human cell; human tissue; immune system; India; inflammation; leukopenia; lymphocyte count; lymphocytosis; major clinical study; male; neutropenia; neutrophil lymphocyte ratio; nonhuman; platelet count; platelet lymphocyte ratio; retrospective study; Severe acute respiratory syndrome coronavirus 2; tertiary care center; thrombocytopenia; biochemical marker; biological marker; C reactive protein; endogenous compound
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Observational study
Language:
English
Journal:
International Journal of Pharmaceutical Sciences Review and Research
Year:
2023
Document Type:
Article
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