Carbon nanotube substrates enhance SARS-CoV-2 spike protein ion yields in matrix-assisted laser desorption-ionization mass spectrometry
Applied Physics Letters
; 122(5), 2023.
Article
in English
| Scopus | ID: covidwho-2244962
ABSTRACT
Nanostructured surfaces enhance ion yields in matrix-assisted laser desorption-ionization mass spectrometry (MALDI-MS). The spike protein complex, S1, is one fingerprint signature of Sars-CoV-2 with a mass of 75 kDa. Here, we show that MALDI-MS yields of Sars-CoV-2 spike protein ions in the 100 kDa range are enhanced 50-fold when the matrix-analyte solution is placed on substrates that are coated with a dense forest of multi-walled carbon nanotubes, compared to yields from uncoated substrates. Nanostructured substrates can support the development of mass spectrometry techniques for sensitive pathogen detection and environmental monitoring. © 2023 Author(s).
Desorption; Ionization; Mass spectrometry; Multiwalled carbon nanotubes (MWCN); Proteins; Analytes; Ion yields; matrix; Matrix-assisted laser desorption ionization mass spectrometry; Multi-walled-carbon-nanotubes; Nanostructured substrates; Nanostructured surface; Protein complexes; Protein ions; Spike protein; Ions
Full text:
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Collection:
Databases of international organizations
Database:
Scopus
Language:
English
Journal:
Applied Physics Letters
Year:
2023
Document Type:
Article
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