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Can the triumph of mRNA vaccines against COVID-19 be extended to other viral infections of humans and domesticated animals?
Sehrawat, Sharvan; Osterrieder, Nikolaus; Schmid, D Scott; Rouse, Barry T.
  • Sehrawat S; Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, SAS Nagar Knowledge City PO Manauli, Mohali 140306 Punjab India. Electronic address: sharvan@iisermohali.ac.in.
  • Osterrieder N; Institut für Virologie, Freie Universität Berlin, Robert-von-Ostertag-Str. 7-13, 14163 Berlin, Germany; Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, 5F, Block 1B, To Yuen Building, 31 To Yuen Street,
  • Schmid DS; Independent Contract Consultant; Associate Professor Adjoint, University of Colorado Boulder, Department of Molecular, Cellular and Developmental Biology, Boulder, CO.
  • Rouse BT; College of Veterinary MedicineUniversity of Tennessee Knoxville, TN 37996-0845 USA. Electronic address: btr@utk.edu.
Microbes Infect ; : 105078, 2022 Nov 23.
Article in English | MEDLINE | ID: covidwho-2245025
ABSTRACT
The unprecedented success of mRNA vaccines in managing the COVID-19 pandemic raises the prospect of applying the mRNA platform to other viral diseases of humans and domesticated animals, which may lead to more efficacious vaccines for some agents. We briefly discuss reasons why mRNA vaccines achieved such success against COVID-19 and indicate what other virus infections and disease conditions might also be ripe for control using mRNA vaccines. We also evaluate situations where mRNA could prove valuable to rebalance the status of immune responsiveness and achieve success as a therapeutic vaccine approach against infections that induce immunoinflammatory lesions.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Vaccines Language: English Journal: Microbes Infect Journal subject: Allergy and Immunology / Microbiology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Vaccines Language: English Journal: Microbes Infect Journal subject: Allergy and Immunology / Microbiology Year: 2022 Document Type: Article