The Effect of Carriage of CYP3A5*3 and CYP3A4*22 Polymorphic Variants on the Safety of Remdesivir Therapy in Patients with COVID-19
Antibiotiki i Khimioterapiya
; 67(45145):45-50, 2022.
Article
in Russian
| EMBASE | ID: covidwho-2245708
ABSTRACT
The aim of the study was to assess the association of polymorphic variants CYP3A5*3 6986 A>G rs776746 and CYP3A4*22 rs35599367 C>T with the safety parameters of remdesivir therapy in patients with COVID-19. Material and methods. The study included 156 patients admitted to the City Clinical Hospital No. 15 of the Moscow Health Department with COVID-19 diagnosis, who received remdesivir as an antiviral drug. The frequency of adverse reactions (bradycardia, dyspeptic disorders), as well as various laboratory parameters (ALT, AST, creatinine, ferritin, interleukin-6, and d-dimer levels) were compared between the carriers of wild-type and polymorphic variants of the studied genes. Results. Carriers of CYP3A5*3 polymorphic variants (GA+AA) had higher ALT levels after the treatment with remdesivir than carriers of the wild variant (GG). When comparing the level of interleukin-6 after therapy with remdesivir, carriers of the polymorphic variant of the CYP3A4*22 (CT) gene had a significantly higher level of this cytokine. Conclusion. An association between the carriage of polymorphic variants of CYP3A5*3 and an increase in the level of liver enzymes was found. Polymorphic variants of CYP3A4*22 were associated with higher levels of interleukin-6. Additional pharmacogenetic studies are required to assess the possibilities of personalizing antiviral therapy for COVID-19.
adult; alanine aminotransferase blood level; antiviral therapy; article; aspartate aminotransferase level; bradycardia; controlled study; coronavirus disease 2019; drug safety; drug therapy; dyspepsia; female; ferritin blood level; gene expression; gene frequency; human; major clinical study; male; pharmacogenetic testing; protein expression; public health service; Russian Federation; single nucleotide polymorphism; wild type; antivirus agent; creatinine; cytochrome P450 3A4; cytochrome P450 3A5; cytokine; D dimer; endogenous compound; ferritin; interleukin 6; liver enzyme; remdesivir
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
Topics:
Variants
Language:
Russian
Journal:
Antibiotiki i Khimioterapiya
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS