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The effect of Fingolimod on patients with moderate to severe COVID-19.
Teymouri, Soheil; Pourbayram Kaleybar, Siamak; Hejazian, Seyyed Sina; Hejazian, Seyyedeh Mina; Ansarin, Khalil; Ardalan, Mohammadreza; Zununi Vahed, Sepideh.
  • Teymouri S; Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Pourbayram Kaleybar S; Kidney Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Hejazian SS; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Hejazian SM; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Ansarin K; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Ardalan M; Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Zununi Vahed S; Kidney Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Pharmacol Res Perspect ; 11(1): e01039, 2023 02.
Article in English | MEDLINE | ID: covidwho-2245726
ABSTRACT
Hyper-inflammation, cytokine storm, and recruitment of immune cells lead to uncontrollable endothelial cell damage in patients with coronavirus disease 2019 (COVID-19). Sphingosine 1-phosphate (S1P) signaling is needed for endothelial integrity and its decreased serum level is a predictor of clinical severity in COVID-19. In this clinical trial, the effect of Fingolimod, an agonist of S1P, was evaluated on patients with COVID-19. Forty patients with moderate to severe COVID-19 were enrolled and divided into two groups including (1) the control group (n = 21) receiving the national standard regimen for COVID-19 patients and (2) the intervention group (n = 19) that prescribed daily Fingolimod (0.5 mg) for 3 days besides receiving the standard national regimen for COVID-19. The hospitalization period, re-admission rate, intensive care unit (ICU) administration, need for mechanical ventilation, and mortality rate were assessed as primary outcomes in both groups. The results showed that re-admission was significantly decreased in COVID-19 patients who received Fingolimod compared to the controls (p = .04). In addition, the hemoglobin levels of the COVID-19 patients in the intervention group were increased compared to the controls (p = .018). However, no significant differences were found regarding the intubation or mortality rate between the groups (p > .05). Fingolimod could significantly reduce the re-admission rate after hospitalization with COVID-19. Fingolimod may not enhance patients' outcomes with moderate COVID-19. It is necessary to examine these findings in a larger cohort of patients with severe to critical COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Pharmacol Res Perspect Year: 2023 Document Type: Article Affiliation country: Prp2.1039

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Pharmacol Res Perspect Year: 2023 Document Type: Article Affiliation country: Prp2.1039