[Posterior reversible encephalopathy síndrome in critical COVID-19 patients: report of two cases.] / Síndrome de encefalopatía posterior reversible en pacientes críticos COVID-19: reporte de dos casos.
Rev Esp Anestesiol Reanim (Engl Ed)
; 2021 Jul 30.
Article
in Spanish
| MEDLINE | ID: covidwho-2245815
ABSTRACT
Posterior reversible encephalopathy syndrome (PRES) is an acute neurological disorder characterized by variable symptoms and radiological images characteristic of vasogenic parietal-occipital edema. It is associated with clinical conditions such as high blood pressure, infection / sepsis, or cytotoxic / immunosuppressive drugs, among others. It is characterized pathophysiologically by endothelial damage with breakdown of blood-brain barrier (BBB), cerebral hypoperfusion, and vasogenic edema.The cases are presented on two critical COVID-19 patients who were admitted to pneumonia requiring mechanical ventilation and who, after removing sedation, developed acute and reversible neurological symptoms consisting of epilepsy and encephalopathy, associated with hyperintense subcortical lesions on brain magnetic resonance imaging (MRI) compatible with PRES.SARS-CoV-2 coronavirus would activate an inflammatory response that would damage brain endothelium. It could be triggered by cytokine release, as well as by direct viral injury, given that endothelium expresses ACE2 receptors. It could explain the possible association between PRES and COVID-19.
Full text:
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Collection:
International databases
Database:
MEDLINE
Type of study:
Case report
/
Prognostic study
Language:
Spanish
Year:
2021
Document Type:
Article
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