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Efficacy, Safety and Immunogenicity of Anti-SARS-CoV-2 Vaccines in Patients with Cirrhosis: A Narrative Review.
Toutoudaki, Konstantina; Dimakakou, Melitini; Androutsakos, Theodoros.
  • Toutoudaki K; First Department of Pediatrics, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Dimakakou M; Department of Gynecology and Obstetrics, General Hospital of Chalkida, 34100 Chalkida, Greece.
  • Androutsakos T; Pathophysiology Department, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Vaccines (Basel) ; 11(2)2023 Feb 16.
Article in English | MEDLINE | ID: covidwho-2245820
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19), has led to a pandemic with more than 6.5 million deaths worldwide. Patients with liver cirrhosis (PWLC) are regarded as prone to severe COVID-19. Vaccination against SARS-CoV-2 has been proven to be the most effective measure against COVID-19 and a variety of different vaccines have been approved for use; namely mRNA and vector-based, inactivated, whole virion, and protein subunit vaccines. Unfortunately, only a small number of PWLC were included in phase I-III vaccine trials, raising concerns regarding their efficacy and safety in this population. The authors, in this review, present available data regarding safety and efficacy of anti-SARS-CoV-2 vaccination in PWLC and discuss post-vaccination antibody responses. Overall, all vaccines seem to be extremely safe, with only a few and insignificant adverse events, and efficient, leading to lower rates of hospitalization and COVID-19-related mortality. T- and B-cell responses, on the other hand, remain an enigma, especially in patients with decompensated disease, since these patients show lower titers of anti-SARS-CoV-2 antibodies in some studies, with a more rapid waning. However, this finding is not consistent, and its clinical impact is still undetermined.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Reviews Topics: Vaccines Language: English Year: 2023 Document Type: Article Affiliation country: Vaccines11020452

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Reviews Topics: Vaccines Language: English Year: 2023 Document Type: Article Affiliation country: Vaccines11020452