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Sex, Racial, and Ethnic Representation in COVID-19 Clinical Trials: A Systematic Review and Meta-analysis.
Xiao, Hong; Vaidya, Riha; Liu, Fang; Chang, Ximing; Xia, Xiaoqian; Unger, Joseph M.
  • Xiao H; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.
  • Vaidya R; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.
  • Liu F; Public Health Emergency Center, Chinese Center for Disease Control and Prevention, Beijing, China.
  • Chang X; School of Public Health, Imperial College London, London, England, United Kingdom.
  • Xia X; School of Nursing, Peking University Health Science Center, Beijing, China.
  • Unger JM; School of Public Health, London School of Hygiene and Tropical Medicine, London, England, United Kingdom.
JAMA Intern Med ; 2022 Dec 05.
Article in English | MEDLINE | ID: covidwho-2246440
ABSTRACT
Importance Since the onset of the COVID-19 pandemic, there have been calls for COVID-19 clinical trials to be fully representative of all demographic groups. However, limited evidence is available about the sex, racial, and ethnic representation among COVID-19 prevention and treatment trials.

Objective:

To investigate whether female participants and racial and ethnic minority individuals are adequately represented in COVID-19 prevention and treatment trials in the US. Data Sources Identified studies were registered on ClinicalTrials.gov or published in the PubMed database from October 2019 to February 2022. Study Selection Included studies must have provided the number of enrolled participants by sex, race, or ethnicity. Only interventional studies conducted in the US for the primary purpose of the diagnosis, prevention, or treatment of (or supportive care for) COVID-19 conditions were included. Data Extraction and

Synthesis:

Data on counts of enrollments by demographic variables (sex, race, and ethnicity) and location (country and state) were abstracted. Studies were broadly categorized by primary purpose as prevention (including vaccine and diagnosis studies) vs treatment (including supportive care studies). A random effects model for single proportions was used. Trial estimates were compared with corresponding estimates of representation in the US population with COVID-19. Main Outcomes and

Measures:

Sex, racial, and ethnic representation in COVID-19 clinical trials compared with their representation in the US population with COVID-19.

Results:

Overall, 122 US-based COVID-19 clinical trials comprising 176 654 participants were analyzed. Studies were predominantly randomized trials (n = 95) for treatment of COVID-19 (n = 103). Sex, race, and ethnicity were reported in 109 (89.3%), 95 (77.9%), and 87 (71.3%) trials, respectively. Estimated representation in prevention and treatment trials vs the US population with COVID-19 was 48.9% and 44.6% vs 52.4% for female participants; 23.0% and 36.6% vs 17.7% for Hispanic or Latino participants; 7.2% and 16.5% vs 14.1% for Black participants; 3.8% and 4.6% vs 3.7% for Asian participants; 0.2% and 0.9% vs 0.2% for Native Hawaiian or Other Pacific Islander participants; and 1.3% and 1.4% vs 1.1% for American Indian or Alaska Native participants. Compared with expected rates in the COVID-19 reference population, female participants were underrepresented in treatment trials (85.1% of expected; P < .001), Black participants (53.7% of expected; P = .003) and Asian participants (64.4% of expected; P = .003) were underrepresented in prevention trials, and Hispanic or Latino participants were overrepresented in treatment trials (206.8% of expected; P < .001). Conclusions and Relevance In this systematic review and meta-analysis, aggregate differences in representation for several demographic groups in COVID-19 prevention and treatment trials in the US were found. Strategies to better ensure diverse representation in COVID-19 studies are needed, especially for prevention trials.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Vaccines Language: English Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Vaccines Language: English Year: 2022 Document Type: Article