Your browser doesn't support javascript.
Is antenatal or early-life vitamin D associated with eczema or food allergy in childhood? A systematic review.
Zeng, Rong; Li, Yusi; Shen, Songying; Qiu, Xiu; Chang, Chia-Lun; Koplin, Jennifer J; Perrett, Kirsten P; Dharmage, Shyamali C; Lodge, Caroline J; Lowe, Adrian J.
  • Zeng R; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Carlton, Victoria, Australia.
  • Li Y; Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
  • Shen S; Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
  • Qiu X; Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
  • Chang CL; Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
  • Koplin JJ; Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
  • Perrett KP; Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
  • Dharmage SC; Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
  • Lodge CJ; Department of Women's Health, Guangdong Provincial Key Clinical Specialty of Woman and Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
  • Lowe AJ; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Carlton, Victoria, Australia.
Clin Exp Allergy ; 53(5): 511-525, 2023 05.
Article in English | MEDLINE | ID: covidwho-2246688
ABSTRACT

OBJECTIVE:

To summarise the associations between antenatal or early-life blood vitamin D and the development of eczema/food allergy in childhood.

DESIGN:

A systematic review and meta-analyses were conducted to synthesize the published literature. Two reviewers independently performed the study selection and data extraction on Covidence. We assessed the risk of bias for observational studies by using the Newcastle-Ottawa Scale and the Cochrane Risk of Bias tool for clinical trials. The certainty of the evidence was assessed using Grading of Recommendations, Assessment, Development and Evaluations (GRADE). DATA SOURCES We systematically searched PubMed and Embase from inception and April 2022. ELIGIBILITY CRITERIA Human studies that investigated prospective associations between antenatal or early-life blood vitamin D levels, dietary intake or supplementation and childhood eczema/food allergy.

RESULTS:

Forty-three articles including six randomised controlled trials (RCTs) were included. Four RCTs of vitamin D supplementation during pregnancy showed no evidence of an effect on the incidence of eczema (pooled odds ratio [OR] = 0.85; 0.67-1.08, I2  = 6.7%, n = 2074). Three RCTs reported null associations between supplementation in pregnancy/infancy and food allergy. From six cohort studies, increasing cord blood vitamin D levels were associated with reduced prevalence of eczema at/close to age one (OR per 10 nmol/L increase = 0.89; 0.84-0.94, I2  = 0%, 2025 participants). We found no evidence of an association between maternal antenatal or infant vitamin D level or dietary intake and the development of food allergy or eczema in offspring.

CONCLUSIONS:

We found an association between higher vitamin D levels in cord blood and reduced risk of eczema in cohort studies. Further trials with maternal and infant supplementation are needed to confirm if vitamin D supplementation can effectively prevent eczema or food allergy in childhood. SYSTEMATIC REVIEW REGISTRATION PROSPERO, No. CRD42013005559.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D Deficiency / Dermatitis, Atopic / Eczema / Food Hypersensitivity Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Female / Humans / Infant / Pregnancy Language: English Journal: Clin Exp Allergy Journal subject: Allergy and Immunology Year: 2023 Document Type: Article Affiliation country: Cea.14281

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D Deficiency / Dermatitis, Atopic / Eczema / Food Hypersensitivity Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Female / Humans / Infant / Pregnancy Language: English Journal: Clin Exp Allergy Journal subject: Allergy and Immunology Year: 2023 Document Type: Article Affiliation country: Cea.14281