Surface control approach for growth of cerium oxide on flower-like molybdenum disulfide nanosheets enables superior removal of uremic toxins
Journal of Colloid and Interface Science
; 630:855-865, 2023.
Article
in English
| Scopus | ID: covidwho-2246767
ABSTRACT
Due to the high incidence of kidney disease, there is an urgent need to develop wearable artificial kidneys. This need is further exacerbated by the coronavirus disease 2019 pandemic. However, the dialysate regeneration system of the wearable artificial kidney has a low adsorption capacity for urea, which severely limits its application. Therefore, nanomaterials that can effectively remove uremic toxins, especially urea, to regenerate dialysate are required and should be further investigated and developed. Herein, flower-like molybdenum disulphide (MoS2) nanosheets decorated with highly dispersed cerium oxide (CeO2) were prepared (MoS2/CeO2), and their adsorption performances for urea, creatinine, and uric acid were studied in detail. Due to the open interlayer structures and the combination of MoS2 and CeO2, which can provide abundant adsorption active sites, the MoS2/CeO2 nanomaterials present excellent uremic toxin adsorption activities. Further, uremic toxin adsorption capacities were also assessed using a self-made fixed bed device under dynamic conditions, with the aim of developing MoS2/CeO2 for the practical adsorption of uremic toxins. In addition, the biocompatibility of MoS2/CeO2 was systematically analyzed using hemocompatibility and cytotoxicity assays. Our data suggest that MoS2/CeO2 can be safely used for applications requiring close contact with blood. Our findings confirm that novel 2-dimensional nanomaterial adsorbents have significant potential for dialysis fluid regeneration. © 2022
Adsorption; Cerium; COVID-19; Dialysis Solutions; Humans; Molybdenum; Urea; Uremic Toxins; Artificial organs; Biocompatibility; Cerium oxide; Layered semiconductors; Metabolism; Molybdenum disulfide; Nanosheets; Nanostructured materials; Oxides; Toxic materials; creatinine; fibrin; fibrinogen; human serum albumin; hydrochloric acid; nanosheet; oxygen; oxygen derivative; proton; thiourea; uric acid; ceric oxide; dialysis fluid; uremic toxin; Adsorption capacities; Artificial kidney; Control approach; Dialysates; High incidence; Kidney disease; Molybdenum disulfide nanosheets; Regeneration system; Surface controls; 4T1 cell line; activated partial thromboplastin time; animal cell; apoptosis; aqueous solution; Article; blood clotting; blood compatibility; cell viability assay; chemical composition; chemisorption; controlled study; crystal; cytotoxicity assay; decomposition; dispersion; Fourier transform infrared spectroscopy; hemolysis; high resolution transmission electron microscopy; kinetics; macromolecule; mouse; nonhuman; oxidation; prothrombin time; rate constant; surface area; surface property; synthesis; thermogravimetry; thrombin time; transmission electron microscopy; X ray diffraction; X ray photoemission spectroscopy; zeta potential; chemistry; human; Dialysate
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Collection:
Databases of international organizations
Database:
Scopus
Language:
English
Journal:
Journal of Colloid and Interface Science
Year:
2023
Document Type:
Article
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