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Potent Therapeutic Strategies for COVID-19 with Single-Domain Antibody Immunoliposomes Neutralizing SARS-CoV-2 and Lip/cGAMP Enhancing Protective Immunity.
Zhou, Yajun; Lu, Xing; Wang, Xiaoqing; Ying, Tianlei; Tan, Xiangshi.
  • Zhou Y; Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, China.
  • Lu X; Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, China.
  • Wang X; Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, China.
  • Ying T; Institutes of Biomedical Sciences, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Tan X; Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, China.
Int J Mol Sci ; 24(4)2023 Feb 17.
Article in English | MEDLINE | ID: covidwho-2246813
ABSTRACT
The worldwide spread of COVID-19 continues to impact our lives and has led to unprecedented damage to global health and the economy. This highlights the need for an efficient approach to rapidly develop therapeutics and prophylactics against SARS-CoV-2. We modified a single-domain antibody, SARS-CoV-2 VHH, to the surface of the liposomes. These immunoliposomes demonstrated a good neutralizing ability, but could also carry therapeutic compounds. Furthermore, we used the 2019-nCoV RBD-SD1 protein as an antigen with Lip/cGAMP as the adjuvant to immunize mice. Lip/cGAMP enhanced the immunity well. It was demonstrated that the combination of RBD-SD1 and Lip/cGAMP was an effective preventive vaccine. This work presented potent therapeutic anti-SARS-CoV-2 drugs and an effective vaccine to prevent the spread of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / Single-Domain Antibodies / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Vaccines Limits: Animals Language: English Year: 2023 Document Type: Article Affiliation country: Ijms24044068

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / Single-Domain Antibodies / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Vaccines Limits: Animals Language: English Year: 2023 Document Type: Article Affiliation country: Ijms24044068