Expert consensus on diagnosis and treatment of SARS-CoV-2 infection in solid organ transplant recipients (2023 edition).

ABSTRACT

Since the end of 2019, the SARS-CoV-2 infection pandemic has swept the world. Although the current SARS-CoV-2 mutants have decreased in pathogenicity and virulence compared with the original strains, and most patients have a good prognosis, the solid organ transplant (SOT) recipients are vulnerable to SARS-CoV-2. And even with vaccination, the risk of hospitalization or death is still high in SOT recipients infected with SARS-CoV-2. What's more, the clinical manifestations, diagnosis and treatment strategy of SOT recipients infected with SARS-CoV-2 has its unique features, which needs high attention. At present, there is a lack of guidelines or consensus in the diagnosis and treatment field of SARS-CoV-2 for such a large number of SOT recipients. Therefore, referring to the "Diagnosis and treatment regimen for SARS-CoV-2 infection (Trial Version 10)” and global published literature, the writing team wrote the "Expert consensus on diagnosis and treatment of SARS-CoV-2 infection in solid organ transplantation recipients (2023 edition)” . This consensus was evidencebased written and reached by experts after multiple rounds of discussions, forming 21 recommendations, providing reference for the diagnosis and treatment of SOT recipients infected with SARS-CoV-2. (English) [ FROM AUTHOR] 自 2019 年底以来, 新型冠状病毒 (新冠病毒) 感染大流行已席卷全球. 虽然目前的新冠病毒变异 株的致病性和毒力已较原始株有所下降, 大多数患者预后良好, 但实体器官移植 (SOT) 受者为新冠病毒感染脆 弱人群, 即使全程接种新冠病毒疫苗, SOT 受者感染新冠病毒的住院或死亡风险依然较高. SOT 受者新冠病毒感 染后其临床表现、诊断和治疗均与普通人群存在很大的特殊性, 需要高度关注. 目前尚缺乏针对 SOT 受者可供 参考的新冠病毒感染诊疗领域的指南或共识. 因此, 参考《新型冠状病毒感染诊疗方案 (试行第十版) 》及国内 外文献, 编写团队撰写了《实体器官移植受者新型冠状病毒感染诊疗专家共识 (2023 年版) 》. 本共识基于国内 外新冠病毒感染的循证医学证据, 并经过专家多次研讨达成一致意见后撰写成文, 形成 21 条推荐意见, 为 SOT 受者感染新冠病毒的诊疗提供参考. (Chinese) [ FROM AUTHOR] Copyright of Organ Transplantation / Qi Guan Yi Zhi is the property of Organ Transplantation Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)