Increased CD4/CD8 T-cell ratio: a risk factor for mortality in patients with coronavirus disease 2019
Medical Journal of Malaysia
; 77(Suppl. 1):31-34, 2022.
Article
in English
| GIM | ID: covidwho-2248085
ABSTRACT
Introduction:
Although CD4 and CD8 T-cells are the main subset of T-lymphocytes, their roles in COVID-19 infection and severity remain unclear. This study aimed to determine the role of increased CD4/CD8 T-cells ratio as a risk factor for cases of 28-days in-hospital mortality in COVID-19 patients. Materials andMethods:
This study employed a prospective cohort design. Inclusion criteria were confirmed COVID-19 cases with a positive polymerase chain reaction report. CD4 and CD8 T-cells absolute counts were measured by flow cytometry. The CD4/CD8 ratio was calculated by dividing the absolute count of CD4 by that of CD8 T-cells.Results:
A total of 85 subjects were followed for 28 days. The mean age of the subjects was 52.64 years, and majority of them were females (51.8%). Twenty-eight (32.9%) subjects died within 28 days of follow-up. Receiver operating characteristics analysis obtained an area under curve of 0.68 with the cut-off value 1.26 with p = 0.005. Kaplan-Meier's analysis obtained Hazard Ratio 2.91 (95%CI 1.377-6.161;p = 0.0052).Conclusion:
Subjects with an increase in CD4/CD8 T-cells ratio >1.26 had a 2.91-times risk of 28 days in-hospital mortality.
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Collection:
Databases of international organizations
Database:
GIM
Type of study:
Prognostic study
Language:
English
Journal:
Medical Journal of Malaysia
Year:
2022
Document Type:
Article
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