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The Effect of COVID-19 on Long-Term Cardiac Function in Patients With Chronic Heart Failure.
Ageev, A A; Kozhevnikova, M V; Emelyanov, A V; Krivova, A V; Shumskaya, Yu F; Musaeva, L M; Popova, L V; Naymann, Yu I; Abdullaeva, G B; Privalova, E V; Belenkov, Yu N.
  • Ageev AA; Sechenov First Moscow State Medical University (Sechenov University), Moscow.
  • Kozhevnikova MV; Sechenov First Moscow State Medical University (Sechenov University), Moscow.
  • Emelyanov AV; Sechenov First Moscow State Medical University (Sechenov University), Moscow.
  • Krivova AV; Sechenov First Moscow State Medical University (Sechenov University), Moscow.
  • Shumskaya YF; Scientific and Practical Clinical Center for Diagnostics and Telemedicine Technologies, Moscow.
  • Musaeva LM; Sechenov First Moscow State Medical University (Sechenov University), Moscow.
  • Popova LV; Sechenov First Moscow State Medical University (Sechenov University), Moscow.
  • Naymann YI; Sechenov First Moscow State Medical University (Sechenov University), Moscow.
  • Abdullaeva GB; Sechenov First Moscow State Medical University (Sechenov University), Moscow.
  • Privalova EV; Sechenov First Moscow State Medical University (Sechenov University), Moscow.
  • Belenkov YN; Sechenov First Moscow State Medical University (Sechenov University), Moscow.
Kardiologiia ; 62(12): 23-29, 2022 Dec 31.
Article in Russian, English | MEDLINE | ID: covidwho-2248180
ABSTRACT
Aim      To evaluate functional changes in the heart in the long-term following COVID-19 in patients with chronic heart failure (CHF).Material and methods  Case reports of 54 patients aged 69.1±9.7 years who had COVID-19 from January 2021 through January 2022 and had been previously diagnosed with NYHA functional class II-III CHF were studied. Two comparison groups were isolated HF with LV EF >50 % (n=39) and <50 % (n=15). Echocardiography was used to evaluate changes in LV EF and pulmonary artery systolic pressure (PASP) 5-6 months following COVID-19.Results In all CHF patients after COVID-19 at 5.8 months on average, LV EF decreased (median difference, 2.5 %; 95 % confidence interval (CI) 6.99×10-5- 4.99) and PASP increased (median difference, 8 mm Hg; 95 % CI 4.5-12.9). In the HF group with LV EF <50 %, the decrease in EF was greater than in the group with LV EF >50 % (6.9 and 0.7 %, respectively; p=0.037); furthermore, the CHF phenotype did not influence the change in PASP (p=0.4). The one-factor regression analysis showed that the dynamics of LV EF decrease was significantly influenced by the baseline decrease in LV EF, whereas the change in PASP was influenced by the dynamics of LV EF decrease, presence of dyslipidemia, and statin treatment. Furthermore, the multifactorial analysis showed that prognostically significant factors for long-term changes in LV EF following COVID-19 were male gender (odds ratio (OR), 5.92; 95 % CI 1.31-26.75; p=0.014), LV EF at baseline <50 % (OR, 0.88; 95 % CI 0.8-0.96; p<0.001); changes in PASP depended on the presence of dyslipidemia (OR, 0.08; 95 % CI 0.01-0.84; p=0.018).Conclusion      This study showed that COVID-19 in the long term can influence the course of CHF; in this process, HF patients with EF <50 % have progression of systolic dysfunction and PASP, whereas patients with EF >50 % have an isolated increase in PASP.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Heart Failure Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male Language: English / Russian Journal: Kardiologiia Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Heart Failure Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male Language: English / Russian Journal: Kardiologiia Year: 2022 Document Type: Article