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Natural Products as Potential Therapeutic Agents for SARS-CoV-2: A Medicinal Chemistry Perspective.
Aggarwal, Varun; Bala, Ekta; Kumar, Pawan; Raizada, Pankaj; Singh, Pardeep; Verma, Praveen Kumar.
  • Aggarwal V; School of Advanced Chemical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, H.P., 173229, India.
  • Bala E; School of Advanced Chemical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, H.P., 173229, India.
  • Kumar P; School of Physics and Material Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, H.P., 173229, India.
  • Raizada P; School of Advanced Chemical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, H.P., 173229, India.
  • Singh P; School of Advanced Chemical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, H.P., 173229, India.
  • Verma PK; School of Advanced Chemical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, H.P., 173229, India.
Curr Top Med Chem ; 2023 Mar 27.
Article in English | MEDLINE | ID: covidwho-2248194
ABSTRACT
Coronavirus is a single-stranded RNA virus discovered by virologist David Tyrrell in 1960. Till now seven human corona viruses have been identified including HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1, SARS-CoV, MERS-CoV and SARS-CoV-2. In the present scenario, the SARS-CoV-2 outbreak causing SARS-CoV-2 pandemic, became the most serious public health emergency of the century worldwide. Natural products have long history and advantages for the drug discovery process. Almost 80% of drugs present in market are evolved from the natural resources. With the outbreak of SARS-CoV-2 pandemic, natural product chemists have made significant efforts for the identification of natural molecules which can be effective against the SARS-CoV-2. In current compilation we have discussed in vitro and in vivo anti-viral potential of natural product-based leads for the treatment of SARS-CoV-2. We have classified these leads in different classes of natural products such as alkaloids, terpenoids, flavonoids, polyphenols, quinones, cannabinoids, steroids, glucosinolates, diarylheptanoids, etc. and discussed the efficacy and mode of action of these natural molecules. The present review will surely opens new direction in future for the development of promising drug candidates particularly from the natural origin against coronaviruses and other viral diseases.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal subject: Chemistry Year: 2023 Document Type: Article Affiliation country: 1568026623666230327125918

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal subject: Chemistry Year: 2023 Document Type: Article Affiliation country: 1568026623666230327125918