COVID-19 vaccination and menstrual disorders among women: Findings from a meta-analysis study.
J Infect Public Health
; 16(5): 697-704, 2023 May.
Article
in English
| MEDLINE | ID: covidwho-2248582
ABSTRACT
BACKGROUND:
COVID - 19 vaccine can lead to various local and systemic side effects, including menstrual irregularities in women. There is no robust quantitative evidence of the association between the COVID - 19 vaccine and menstrual irregularities. A meta-analysis was performed to estimate the pooled prevalence of a range of menstrual disorders that may occur in women following COVID - 19 vaccination.METHODS:
After searching for epidemiological studies, we systematically performed a meta-analysis on PubMed/Medline, EMBASE, and Science Direct. Sixteen studies were finally included in the study. We estimated the pooled prevalence and corresponding 95 % confidence intervals (CIs) for a group of menstrual disorders, including menorrhagia, polymenorrhea, abnormal cycle length, and oligomenorrhea. Heterogeneity was assessed using the I2 statistic and the Q test.RESULTS:
Overall, the pooled prevalence of menorrhagia was 24.24 % (pooled prevalence 24.24 %; 95 % CI 12.8-35.6 %). The pooled prevalence of polymenorrhea was 16.2 % (pooled prevalence 16.2 %; 95 % CI 10.7-21.6 %). The pooled prevalence of abnormal cycle length was relatively lower than that of the other disorders (pooled prevalence 6.6 %; 95 % CI 5.0-8.2 %). The pooled prevalence of oligomenorrhea was 22.7 % (95 % CI 13.5-32.0 %).CONCLUSION:
The findings indicate that menorrhagia, oligomenorrhea, and polymenorrhea were the most common menstrual irregularities after vaccination. The findings also suggest that a relatively high proportion of women suffer from menstrual irregularities. Further longitudinal studies are needed to confirm the causal relationship between COVID-19 vaccination and menstrual irregularities.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19 Vaccines
/
COVID-19
/
Menorrhagia
Type of study:
Cohort study
/
Observational study
/
Prognostic study
/
Reviews
Topics:
Long Covid
/
Vaccines
Limits:
Female
/
Humans
Language:
English
Journal:
J Infect Public Health
Journal subject:
Communicable Diseases
/
Public Health
Year:
2023
Document Type:
Article
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