CORRELATION BETWEEN HEPCIDIN AND PROCALCITONIN AND THEIR DIAGNOSTIC ROLE IN PATIENTS WITH COVID-19.
Wiad Lek
; 76(1): 65-70, 2023.
Article
in English
| MEDLINE | ID: covidwho-2248657
ABSTRACT
OBJECTIVE:
Theaim:
The purpose of this study is to find out the association between procalcitonin and hepcidin in patients with COVID-19, in addition to their role as diagnostic markers. PATIENTS ANDMETHODS:
Materials andmethods:
A total of 75 patients infected with coronavirus were included in the current study, their age is ranging between 20 to 78 years. Those patients was hospitalized in Al-Sadr Teaching Hospital in Najaf, in Iraq. This study also included 50 healthy subjects which are volunteers and considered as a (control group). Biomarker (procalcitonin and hepcidin) measurements were achieved by electrochemiluminescent immunoassay (ECLIA) in the Elecsys immunoassay system.RESULTS:
Results:
The present study showed a significant increase the serum cencentration of hepcidin and procalcitonin in patients with COVID-19 as compared tohealthy subjects. There was a highly significant increasing(p < 0.01) in hepcidin and PCT level in patients with severe infection comparing to other catgaries.The current study also revealed that the sensitivity values of the markers were 0.88%, 0.85 for procalcitonin and hepcidin respectively, which indicate high diagnostic power.CONCLUSION:
Conclusions:
Serum levels of hepcidin and procalcitonin are increased as inflammatory markers in COVID-19 patients with relatively high sensitivity. It seems that these imflammatory markers obviously elevate in the severe cases COVID-19dusease.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Hepcidins
/
Procalcitonin
/
COVID-19
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Humans
/
Middle aged
/
Young adult
Country/Region as subject:
Asia
Language:
English
Journal:
Wiad Lek
Journal subject:
Medicine
Year:
2023
Document Type:
Article
Affiliation country:
WLek202301109
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