Importance of IL-1beta in SARS-CoV-2 infection

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provokes the host immune responses and induces severe respiratory syndrome by overreaction of immune cells. IL-1beta is a pro-inflammatory cytokine highly associated with the related inflammation and cytokine storm, and several IL-1beta antagonists are being used to treat cytokine release syndrome (CRS). Accordingly, some studies and clinical trials are investigating the effects of IL-1beta antagonists for controlling Coronavirus disease 2019 (COVID-19) associated CRS. Here, we will review any interaction and association between IL-1beta and SARS-CoV-2 infection.