Ruxolitinib and methylprednisolone for treatment of patients with relapsed/refractory multiple myeloma.
Br J Haematol
; 200(6): 722-730, 2023 03.
Article
in English
| MEDLINE | ID: covidwho-2251898
ABSTRACT
Although Janus kinase (JAK) inhibitors have demonstrated efficacy for treating autoimmune disorders and myeloproliferative neoplasms, their efficacy in treating other types of cancer has not been clearly demonstrated. We evaluated oral ruxolitinib (15 mg twice daily) with oral methylprednisolone (40 mg every other day) for multiple myeloma (MM) patients with progressive disease who had received a proteasome inhibitor, lenalidomide, glucocorticosteroids and three or more prior regimens. All of the planned 29 patients had been enrolled with follow-up until 28 April 2022. Median lines of prior therapy were 6 (range 3-12). Cytogenetics and fluorescent in situ hybridization were evaluable in 28 patients; 9 (32%) and 17 (70%) patients showed high-risk cytogenetics and/or 1q+, respectively. The overall response rate was 31%. The median duration of response was 13.1 (range 2.8-22.0) months. Median progression-free survival rate was 3.4 (range 0.5-24.6) months, Overall, the treatment was well tolerated. The combination of ruxolitinib and methylprednisolone demonstrated significant clinical activity among previously heavily-treated MM patients, and responses were achieved among patients who had high-risk cytogenetics. This is the first clinical study to show activity of JAK inhibitors in combination with steroids for MM patients and expands the potential use of these drugs to those with cancers other than myeloproliferative neoplasms.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Multiple Myeloma
Type of study:
Cohort study
/
Experimental Studies
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Br J Haematol
Year:
2023
Document Type:
Article
Affiliation country:
Bjh.18593
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