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The impact of statin therapy on in-hospital prognosis and endothelial function of patients at high-to-very high cardiovascular risk admitted for COVID-19.
Bianconi, Vanessa; Mannarino, Massimo R; Cosentini, Elena; Figorilli, Filippo; Colangelo, Cecilia; Cellini, Giulia; Braca, Marco; Lombardini, Rita; Paltriccia, Rita; Sahebkar, Amirhossein; Pirro, Matteo.
  • Bianconi V; Department of Medicine and Surgery, Unit of Internal Medicine, University of Perugia, Perugia, Italy.
  • Mannarino MR; Department of Medicine and Surgery, Unit of Internal Medicine, University of Perugia, Perugia, Italy.
  • Cosentini E; Department of Medicine and Surgery, Unit of Internal Medicine, University of Perugia, Perugia, Italy.
  • Figorilli F; Department of Medicine and Surgery, Unit of Internal Medicine, University of Perugia, Perugia, Italy.
  • Colangelo C; Department of Medicine and Surgery, Unit of Internal Medicine, University of Perugia, Perugia, Italy.
  • Cellini G; Department of Medicine and Surgery, Unit of Internal Medicine, University of Perugia, Perugia, Italy.
  • Braca M; Department of Medicine and Surgery, Unit of Internal Medicine, University of Perugia, Perugia, Italy.
  • Lombardini R; Department of Medicine and Surgery, Unit of Internal Medicine, University of Perugia, Perugia, Italy.
  • Paltriccia R; Department of Medicine and Surgery, Unit of Internal Medicine, University of Perugia, Perugia, Italy.
  • Sahebkar A; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Pirro M; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
J Med Virol ; 95(3): e28678, 2023 03.
Article in English | MEDLINE | ID: covidwho-2252186
ABSTRACT
Statins may protect against adverse outcomes from Coronavirus disease 2019 (COVID-19) through their pleiotropic effects. Endothelial dysfunction seems to be implicated in the pathophysiology of COVID-19, and can be attenuated by statins. This study assessed the role of preadmission statin therapy and its interaction with endothelial function, measured using flow-mediated dilation (FMD) at hospital admission, in predicting in-hospital outcomes among patients with COVID-19 having high-to-very high cardiovascular (CV) risk. We conducted a retrospective cohort study of hospitalized patients with COVID-19 having high-to-very high CV risk, including a subgroup of patients who underwent FMD assessment. Among 342 patients, 119 (35%) were treated with statins at study baseline. Preadmission statin therapy was independently associated with a 75% risk reduction of intensive care unit admission/in-hospital death (adjusted hazard ratio 0.252, 95% confidence interval 0.122-0.521, p < 0.001). In the subgroup of patients with an FMD assessment (245 patients, 40% statin-treated), preadmission statin therapy was independently associated with higher FMD values (ß = 0.159, p = 0.013). However, preadmission statin therapy × FMD interaction was not associated with in-hospital outcomes (F = 0.002, pinteraction = 0.960). Preadmission statin therapy is associated with better in-hospital outcomes among patients with COVID-19 having high-to-very high CV risk, independent of the endothelium-protective effects of these drugs.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / Hydroxymethylglutaryl-CoA Reductase Inhibitors / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: J Med Virol Year: 2023 Document Type: Article Affiliation country: Jmv.28678

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / Hydroxymethylglutaryl-CoA Reductase Inhibitors / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: J Med Virol Year: 2023 Document Type: Article Affiliation country: Jmv.28678