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The role of Zn ions in the interaction between SARS-CoV-2 orf7a protein and BST2/tetherin.
Botticelli, S; Chiaraluce, R; Consalvi, V; La Penna, G; Pasquo, A; Petrosino, M; Proux, O; Rossi, G C; Stellato, F; Morante, S.
  • Botticelli S; Università di Roma "Tor Vergata" and INFN, Sezione di Roma 2 - Via della Ricerca Scientifica 1, 00133 Rome, Italy.
  • Chiaraluce R; Dipartimento di Biochimica, Sapienza Universitá di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Consalvi V; Dipartimento di Biochimica, Sapienza Universitá di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • La Penna G; CNR, Institute for Chemistry of Organometallic Compounds, 50019 Sesto Fiorentino, Italy.
  • Pasquo A; ENEA CR Frascati, Diagnostics and Metrology Laboratory FSN-TECFIS-DIM, Via E. Fermi, 45, 00044 Frascati, Italy.
  • Petrosino M; Dipartimento di Biochimica, Sapienza Universitá di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Proux O; Observatoire des Sciences de l'Univers de Grenoble, UMS 832 CNRS, Université Grenoble Alpes, 38041 Grenoble, France.
  • Rossi GC; Università di Roma "Tor Vergata" and INFN, Sezione di Roma 2 - Via della Ricerca Scientifica 1, 00133 Rome, Italy.
  • Stellato F; Centro Fermi - Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Via Panisperna 89a, 00184 Roma, Italy.
  • Morante S; Università di Roma "Tor Vergata" and INFN, Sezione di Roma 2 - Via della Ricerca Scientifica 1, 00133 Rome, Italy.
Eur Phys J Plus ; 138(3): 216, 2023.
Article in English | MEDLINE | ID: covidwho-2252757
ABSTRACT
In this paper, we provide evidence that Zn 2 + ions play a role in the SARS-CoV-2 virus strategy to escape the immune response mediated by the BST2-tetherin host protein. This conclusion is based on sequence analysis and molecular dynamics simulations as well as X-ray absorption experiments [1].

Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Eur Phys J Plus Year: 2023 Document Type: Article Affiliation country: Epjp

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Eur Phys J Plus Year: 2023 Document Type: Article Affiliation country: Epjp