Awake prone position in COVID-19 acute respiratory failure: a randomised crossover study using electrical impedance tomography.
ERJ Open Res
; 9(2)2023 Mar.
Article
in English
| MEDLINE | ID: covidwho-2253150
ABSTRACT
Background:
The goal of this study was to determine whether an awake prone position (aPP) reduces the global inhomogeneity (GI) index of ventilation measured by electrical impedance tomography (EIT) in COVID-19 patients with acute respiratory failure (ARF).Methods:
This prospective crossover study included COVID-19 patients with COVID-19 and ARF defined by arterial oxygen tensioninspiratory oxygen fraction (P aO2F IO2 ) of 100-300â mmHg. After baseline evaluation and 30-min EIT recording in the supine position (SP), patients were randomised into one of two sequences SP-aPP or aPP-SP. At the end of each 2-h step, oxygenation, respiratory rate, Borg scale and 30-min EIT were recorded.Results:
10 patients were randomised in each group. The GI index did not change in the SP-aPP group (baseline 74±20%, end of SP 78±23% and end of aPP 72±20%, p=0.85) or in the aPP-SP group (baseline 59±14%, end of aPP 59±15% and end of SP 54±13%, p=0.67). In the whole cohort, P aO2F IO2 increased from 133±44â mmHg at baseline to 183±66â mmHg in aPP (p=0.003) and decreased to 129±49â mmHg in SP (p=0.03).Conclusion:
In spontaneously breathing nonintubated COVID-19 patients with ARF, aPP was not associated with a decrease of lung ventilation inhomogeneity assessed by EIT, despite an improvement in oxygenation.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Language:
English
Year:
2023
Document Type:
Article
Affiliation country:
23120541.00509-2022
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