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Parkinson disease following COVID-19: Report of six cases.
Calculli, Alessandra; Bocci, Tommaso; Porcino, Mattia; Avenali, Micol; Casellato, Chiara; Arceri, Sebastiano; Regalbuto, Simone; Priori, Alberto; Pisani, Antonio.
  • Calculli A; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
  • Bocci T; IRCCS Mondino Foundation, Pavia, Italy.
  • Porcino M; Department of Health Sciences, "Aldo Ravelli" Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan, Milan, Italy.
  • Avenali M; Department of Health Sciences, Clinical Neurology Unit, "Azienda Socio-Sanitaria Territoriale Santi Paolo e Carlo", University of Milan, Milan, Italy.
  • Casellato C; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
  • Arceri S; IRCCS Mondino Foundation, Pavia, Italy.
  • Regalbuto S; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
  • Priori A; IRCCS Mondino Foundation, Pavia, Italy.
  • Pisani A; Department of Health Sciences, Clinical Neurology Unit, "Azienda Socio-Sanitaria Territoriale Santi Paolo e Carlo", University of Milan, Milan, Italy.
Eur J Neurol ; 30(5): 1272-1280, 2023 05.
Article in English | MEDLINE | ID: covidwho-2253528
ABSTRACT
BACKGROUND AND

PURPOSE:

Core clinical manifestations of COVID-19 include influenza-like and respiratory symptoms. However, it is now evident that neurological involvement may occur during SARS-CoV-2 infection, covering an extensive spectrum of phenotypical manifestations. A major challenge arising from this pandemic is represented by detecting emerging neurological complications following recovery from SARS-CoV-2 infection. To date, a few post-COVID-19-infected subjects diagnosed with Parkinson disease (PD) have been described, raising the possibility of a connection between the infection and neurodegenerative processes. Here, we describe a case series of six subjects who developed PD after COVID-19.

METHODS:

Patients were observed at Scientific Institute for Research and Health Care Mondino Foundation Hospital, Pavia (Italy), and San Paolo University Hospital of Milan (Italy) between March 2021 and June 2022. In all subjects, SARS-CoV-2 infection was confirmed by means of reverse transcriptase polymerase chain reaction from a nasopharyngeal swab. Subjects underwent an accurate neurological evaluation, and neuroimaging studies were performed.

RESULTS:

We describe six subjects who developed PD with an average time window after SARS-CoV-2 infection of 4-7 weeks. Apparently, no relationship with COVID-19 severity emerged, and no overt structural brain abnormalities were found. All subjects experienced unilateral resting tremor at onset and showed a satisfactory response to dopaminergic treatment.

CONCLUSIONS:

Immune responses to SARS-CoV-2 infection have been shown to shape the individual susceptibility to develop long-term consequences. We hypothesize that, in these subjects, COVID-19 has unmasked a latent neurodegenerative process. Characterization of the neuroinflammatory signatures in larger cohorts is warranted, which might provide novel insights into the pathogenesis of PD.
Subject(s)
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Parkinson Disease / COVID-19 / Nervous System Diseases Type of study: Case report / Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Eur J Neurol Journal subject: Neurology Year: 2023 Document Type: Article Affiliation country: Ene.15732

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Parkinson Disease / COVID-19 / Nervous System Diseases Type of study: Case report / Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Eur J Neurol Journal subject: Neurology Year: 2023 Document Type: Article Affiliation country: Ene.15732