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COVID-19 complications in males and females: recent developments.
Chaturvedi, Rahul; Lui, Briana; Aaronson, Jamie A; White, Robert S; Samuels, Jon D.
  • Chaturvedi R; Department of Anesthesiology, Weill Cornell Medicine, 525 East 68th Street, Box 124, New York, NY 10065, USA.
  • Lui B; Weill Cornell Medical College, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
  • Aaronson JA; Department of Anesthesiology, Weill Cornell Medicine, 525 East 68th Street, Box 124, New York, NY 10065, USA.
  • White RS; Department of Anesthesiology, Weill Cornell Medicine, 525 East 68th Street, Box 124, New York, NY 10065, USA.
  • Samuels JD; Department of Anesthesiology, Weill Cornell Medicine, 525 East 68th Street, Box 124, New York, NY 10065, USA.
J Comp Eff Res ; 11(9): 689-698, 2022 06.
Article in English | MEDLINE | ID: covidwho-2254396
ABSTRACT

Aim:

To provide a comprehensive understanding of the varying effects of SARS-CoV-2 infection based on sex.

Methods:

A PubMed search of 470 primary articles was performed, with inclusion based on relevance (sex differences discussed in the target COVID population) and redundancy. PubMed was queried based on title for the keywords "SEX" and "COVID" or "SARS" between 2020 and 2022.

Results:

For COVID-19, males have increased risk for infectivity and intensive care unit admission and worse overall outcomes compared with females. Genetic predispositions, sex hormones, immune system responses and non-biological causes all contribute to the disparity in COVID-19 responses between the sexes. COVID-19 sex-related determinants of morbidity and mortality remain unclear.

Conclusions:

Male sex is a risk factor for several overall worse outcomes related to COVID-19. Investigating the sex impact of COVID-19 is an important part of understanding the behavior of the disease. Future work is needed to further explore these relationships and optimize the management of COVID-19 patients based on sex.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study / Reviews Limits: Female / Humans / Male Language: English Journal: J Comp Eff Res Year: 2022 Document Type: Article Affiliation country: Cer-2022-0027

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study / Reviews Limits: Female / Humans / Male Language: English Journal: J Comp Eff Res Year: 2022 Document Type: Article Affiliation country: Cer-2022-0027