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Potential Anti-SARS-CoV-2 Prodrugs Activated by Phosphorylation and Their Role in the Aged Population.
Chavda, Vivek P; Teli, Divya; Balar, Pankti C; Vaghela, Dixa; Solanki, Hetvi K; Vaishnav, Akta; Vora, Lalitkumar.
  • Chavda VP; Department of Pharmaceutics and Pharmaceutical Technology, L. M. College of Pharmacy, Ahmedabad 380008, India.
  • Teli D; Department of Pharmaceutical Chemistry, L. M. College of Pharmacy, Ahmedabad 380009, India.
  • Balar PC; Pharmacy Section, L. M. College of Pharmacy, Ahmedabad 380008, India.
  • Vaghela D; Pharmacy Section, L. M. College of Pharmacy, Ahmedabad 380008, India.
  • Solanki HK; Pharmacy Section, L. M. College of Pharmacy, Ahmedabad 380008, India.
  • Vaishnav A; Pharmacy Section, L. M. College of Pharmacy, Ahmedabad 380008, India.
  • Vora L; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Molecules ; 28(5)2023 Mar 02.
Article in English | MEDLINE | ID: covidwho-2254456
ABSTRACT
The COVID-19 pandemic has flared across every part of the globe and affected populations from different age groups differently. People aged from 40 to 80 years or older are at an increased risk of morbidity and mortality due to COVID-19. Therefore, there is an urgent requirement to develop therapeutics to decrease the risk of the disease in the aged population. Over the last few years, several prodrugs have demonstrated significant anti-SARS-CoV-2 effects in in vitro assays, animal models, and medical practice. Prodrugs are used to enhance drug delivery by improving pharmacokinetic parameters, decreasing toxicity, and attaining site specificity. This article discusses recently explored prodrugs such as remdesivir, molnupiravir, favipiravir, and 2-deoxy-D-glucose (2-DG) and their implications in the aged population, as well as investigating recent clinical trials.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Prodrugs / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Journal subject: Biology Year: 2023 Document Type: Article Affiliation country: Molecules28052332

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Prodrugs / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Journal subject: Biology Year: 2023 Document Type: Article Affiliation country: Molecules28052332