Research progress on the mechanism of multiple organ dysfunction in patients with COVID-19.
Chinese Journal of Clinical Infectious Diseases
; 14(2):102-106, 2021.
Article
in Chinese
| EMBASE | ID: covidwho-2254566
ABSTRACT
The pathogen of COVID-19 is 2019-nCoV, which belongs to the beta coronavirus. Angiotensin-converting enzyme 2 (ACE2) is the receptor of 2019-nCoV as the same of SARS-CoV. Most of the severe patients were the elderly with underlying diseases, which may be related to the decrease in the number of naive T cells. In addition to pulmonary symptoms, COVID-19 can also cause multiple organ dysfunction and even multiple organ failure (liver, nervous system, heart, kidney, etc.). Pathogenic mechanisms such as direct virus invasion, cytokine storm, endothelial cells damage, and down-regulation of ACE2 may play important roles in the severity of the disease.Copyright © 2021 Chinese Medical Association
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
Chinese
Journal:
Chinese Journal of Clinical Infectious Diseases
Year:
2021
Document Type:
Article
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