Research Advances on the Stability of mRNA Vaccines.
Viruses
; 15(3)2023 03 02.
Article
in English
| MEDLINE | ID: covidwho-2254712
ABSTRACT
Compared to other vaccines, the inherent properties of messenger RNA (mRNA) vaccines and their interaction with lipid nanoparticles make them considerably unstable throughout their life cycles, impacting their effectiveness and global accessibility. It is imperative to improve mRNA vaccine stability and investigate the factors influencing stability. Since mRNA structure, excipients, lipid nanoparticle (LNP) delivery systems, and manufacturing processes are the primary factors affecting mRNA vaccine stability, optimizing mRNA structure and screening excipients can effectively improve mRNA vaccine stability. Moreover, improving manufacturing processes could also prepare thermally stable mRNA vaccines with safety and efficacy. Here, we review the regulatory guidance associated with mRNA vaccine stability, summarize key factors affecting mRNA vaccine stability, and propose a possible research path to improve mRNA vaccine stability.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Commerce
/
Excipients
Topics:
Vaccines
Language:
English
Year:
2023
Document Type:
Article
Affiliation country:
V15030668
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