Enzyme Inhibitors from Gorgonians and Soft Corals.
Mar Drugs
; 21(2)2023 Jan 31.
Article
in English
| MEDLINE | ID: covidwho-2255600
ABSTRACT
For decades, gorgonians and soft corals have been considered promising sources of bioactive compounds, attracting the interest of scientists from different fields. As the most abundant bioactive compounds within these organisms, terpenoids, steroids, and alkaloids have received the highest coverage in the scientific literature. However, enzyme inhibitors, a functional class of bioactive compounds with high potential for industry and biomedicine, have received much less notoriety. Thus, we revised scientific literature (1974-2022) on the field of marine natural products searching for enzyme inhibitors isolated from these taxonomic groups. In this review, we present representative enzyme inhibitors from an enzymological perspective, highlighting, when available, data on specific targets, structures, potencies, mechanisms of inhibition, and physiological roles for these molecules. As most of the characterization studies for the new inhibitors remain incomplete, we also included a methodological section presenting a general strategy to face this goal by accomplishing STRENDA (Standards for Reporting Enzymology Data) project guidelines.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Biological Products
/
Anthozoa
Type of study:
Experimental Studies
/
Randomized controlled trials
Limits:
Animals
Language:
English
Journal subject:
Biology
/
Pharmacology
Year:
2023
Document Type:
Article
Affiliation country:
Md21020104
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