The Cytokine Growth Differentiation Factor-15 and Skeletal Muscle Health: Portrait of an Emerging Widely Applicable Disease Biomarker.
Int J Mol Sci
; 23(21)2022 Oct 29.
Article
in English
| MEDLINE | ID: covidwho-2256618
ABSTRACT
Growth differentiation factor 15 (GDF-15) is a stress-induced transforming growth factor-ß superfamily cytokine with versatile functions in human health. Elevated GDF-15 blood levels associate with multiple pathological conditions, and are currently extensively explored for diagnosis, and as a means to monitor disease progression and evaluate therapeutic responses. This review analyzes GDF-15 in human conditions specifically focusing on its association with muscle manifestations of sarcopenia, mitochondrial myopathy, and autoimmune and viral myositis. The use of GDF-15 as a widely applicable health biomarker to monitor muscle disease is discussed, and its potential as a therapeutic target is explored.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Muscle, Skeletal
/
Growth Differentiation Factor 15
Type of study:
Experimental Studies
/
Prognostic study
Limits:
Humans
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Ijms232113180
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