Novel 68Ga-FAPI PET/CT offers oncologic staging without COVID-19 vaccine-related pitfalls.
J Nucl Med
; 2022 Nov 17.
Article
in English
| MEDLINE | ID: covidwho-2256875
ABSTRACT
In the setting of ongoing SARS-CoV-2 vaccination, vaccine-related tracer uptake in locoregional lymph nodes has become a well-known issue in tumor staging by 18F-FDG PET/CT. 68Ga-FAPI PET/CT is a new oncologic imaging tool that may overcome this limitation. Methods:
We assessed post-vaccine, head-to-head and same-day 18F-FDG and 68Ga-FAPI-46 PET/CT findings in a series of 11 patients from a large prospective imaging registry. All patients with documented tracer uptake in locoregional lymph nodes on PET/CT or PET/MRI, following vaccination within 6 weeks, were eligible for investigation.Result:
Significant visual lymph node uptake adjacent to the injection site was noted in 11/11 (100%) patients with 18F-FDG PET/CT versus 0/11 (0%) with 68Ga-FAPI PET/CT. 18F-FDG detected 73% and 68Ga-FAPI PET/CT 94% of all tumor lesions.Conclusion:
In this case-series study, 68Ga-FAPI showed its potential to avoid 18F-FDG-PET/CT post-vaccination pitfalls and presented superior tumor localization.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Observational study
/
Prognostic study
Topics:
Vaccines
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Jnumed.122.264872
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