Acute and Chronic Demyelinating Neuropathies After COVID-19 Vaccination: A Report of 4 Cases.
J Clin Neuromuscul Dis
; 24(3): 147-156, 2023 Mar 01.
Article
in English
| MEDLINE | ID: covidwho-2256915
ABSTRACT
OBJECTIVES:
To report demyelinating neuropathies after COVID-19 vaccination.METHODS:
Case report.RESULTS:
Four cases of demyelinating neuropathies after COVID-19 vaccination were identified at the University of Nebraska Medical Center from May to September 2021. Three were male and 1 was a female, ages 26-64 years. Three cases received Pfizer-BioNTech vaccine and 1 Johnson & Johnson. Symptom onset ranged from 2 to 21 days after vaccination. Two cases had progressive limb weakness, 3 had facial diplegia, and all had sensory symptoms and areflexia. The diagnosis was acute inflammatory demyelinating polyneuropathy in 1 case and chronic inflammatory demyelinating polyradiculoneuropathy in 3. All cases received treatment with intravenous immunoglobulin, with significant improvement in 3 of 4 who had a long-term outpatient follow-up.CONCLUSIONS:
Continued identification and reporting of cases of demyelinating neuropathies after COVID-19 vaccination is essential to determine whether a causative association is present.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
/
COVID-19
Type of study:
Case report
/
Cohort study
/
Diagnostic study
/
Prognostic study
Topics:
Long Covid
/
Vaccines
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
J Clin Neuromuscul Dis
Journal subject:
Physiology
/
Neurology
Year:
2023
Document Type:
Article
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