The synergistic effect of Cu-MOF nanoparticles and immunomodulatory agent on SARS-CoV-2 inhibition.

Ejsmont, Aleksander; Warowicka, Alicja; Broniarczyk, Justyna; Goscianska, Joanna

Ejsmont, Aleksander; Warowicka, Alicja; Broniarczyk, Justyna; Goscianska, Joanna.

Ejsmont A; Adam Mickiewicz University, Faculty of Chemistry, Department of Chemical Technology, Uniwersytetu Poznanskiego 8, Poznan 61-614, Poland. asiagosc@amu.edu.pl.
Warowicka A; Adam Mickiewicz University, Faculty of Biology, Department of Molecular Virology, Institute of Experimental Biology, Uniwersytetu Poznanskiego 6, Poznan 61-614, Poland.
Broniarczyk J; NanoBioMedical Centre, Wszechnicy Piastowskiej 3, Poznan 61-614, Poland.
Goscianska J; Adam Mickiewicz University, Faculty of Biology, Department of Molecular Virology, Institute of Experimental Biology, Uniwersytetu Poznanskiego 6, Poznan 61-614, Poland.

Chem Commun (Camb) ; 59(33): 4907-4910, 2023 Apr 20.

Article in English | MEDLINE | ID: covidwho-2258011

ABSTRACT

ABSTRACT

In this work, HKUST-1 and Cu-BDC nanoparticles were used as delivery systems for the early anti-COVID-19 drug, hydroxychloroquine. The antiviral MOF/drug combinations significantly reduced the infectivity of SARS-CoV-2, which can be attributed to the nanometric size of the carriers, the presence of copper in the MOF nodes, and the semi-controlled release of the drug.

Subject(s)

COVID-19; Nanoparticles; Humans; SARS-CoV-2; Antiviral Agents/pharmacology; Hydroxychloroquine/pharmacology

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Nanoparticles / COVID-19 Type of study: Experimental Studies Limits: Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2023 Document Type: Article Affiliation country: D3cc00894k

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